使用动物模型研究接触水烟烟雾对妊娠结局的影响。
Investigating the Effects of Exposure to Waterpipe Smoke on Pregnancy Outcomes Using an Animal Model.
作者信息
Khabour Omar F, Alzoubi Karem H, Al-Sheyab Nihaya, Shihadeh Alan, Eissenberg Thomas
机构信息
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan;
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan;
出版信息
Nicotine Tob Res. 2016 May;18(5):585-9. doi: 10.1093/ntr/ntv275. Epub 2015 Dec 17.
INTRODUCTION
In recent years, waterpipe tobacco smoking has been increasing in popularity all over the world. In this study, we explored effects of waterpipe smoking on pregnancy outcomes in rats.
METHODS
Animals were exposed to waterpipe tobacco smoking using a whole body exposure system 2 hours per day during pregnancy. A control group was exposed to fresh air only.
RESULTS
The results showed significant association between exposure to waterpipe smoke during pregnancy and low birth weight (P < .01) and neonatal death (P < .01). In addition, the rate of growth of offspring of the waterpipe group was significantly lower than that of control group as measured by body weight gain during the first 3 months of life (P < .001). No effect was found for waterpipe smoking on mean number of progeny and male to female ratio among offspring.
CONCLUSION
Waterpipe smoking is associated with adverse effects on pregnancy outcomes.
IMPLICATIONS
In this study, we investigated for the first time the effect of waterpipe smoking on pregnancy outcomes using animal model. The results clearly showed that waterpipe smoking is associated with adverse effects on pregnancy outcomes that include low birth weigh, neonatal survival, and growth retardation.
引言
近年来，水烟吸食在全球范围内越来越流行。在本研究中，我们探讨了水烟吸食对大鼠妊娠结局的影响。
方法
在孕期，每天使用全身暴露系统让动物暴露于水烟环境中2小时。对照组仅暴露于新鲜空气中。
结果
结果显示，孕期暴露于水烟烟雾与低出生体重（P <.01）和新生儿死亡（P <.01）之间存在显著关联。此外，通过出生后前3个月的体重增加来衡量，水烟组后代的生长速率显著低于对照组（P <.001）。未发现水烟吸食对后代的平均子代数量和雌雄比例有影响。
结论
水烟吸食与妊娠结局的不良影响有关。
启示
在本研究中，我们首次使用动物模型研究了水烟吸食对妊娠结局的影响。结果清楚地表明，水烟吸食与妊娠结局的不良影响有关，包括低出生体重、新生儿存活和生长发育迟缓。
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