Biotechnology and Biosynthesis Group, Institute of Technology in Polymers and Nanotechnology (ITPN), Engineering Faculty, University of Buenos Aires, Las Heras 2214 (CP 1127AAR), Buenos Aires, Argentina.
Biotechnology and Biosynthesis Group, Institute of Technology in Polymers and Nanotechnology (ITPN), Engineering Faculty, University of Buenos Aires, Las Heras 2214 (CP 1127AAR), Buenos Aires, Argentina.
Carbohydr Polym. 2016 Feb 10;137:198-206. doi: 10.1016/j.carbpol.2015.10.039. Epub 2015 Oct 22.
In recent years acetylated, propionylated and butyrylated starches have received special attention due to their capacity to deliver specific short chain fatty acids (SCFAs) to the colon in a sustained and predictable manner, and thus contribute to maintaining the normal physiologic function of the large bowel and preventing specific diseases. In the current contribution a non-conventional organocatalytic solventless route for the eco-friendly propionylation of corn starch is proposed. The catalyst used in the acylation is a naturally occurring α-hydroxy acid (l-tartaric acid). Propionylated starches with degree of substitution (DS) in the 0.05-1.59 interval were obtained and characterized in terms of chemical structure, morphology, crystallinity, thermal stability and hydrophilicity. Results showed that by the proposed methodology propionylated starch with the DS required for clinical use (i.e. 0.2-0.3) could be obtained within 2-3h of reaction. Characterization results evidenced the progressive loss of crystallinity of starch granules as higher substitution levels were conferred.
近年来，乙酰化、丙酰化和丁酰化淀粉由于能够以持续和可预测的方式将特定的短链脂肪酸（SCFA）递送到结肠，从而有助于维持大肠的正常生理功能并预防特定疾病，因此受到了特别关注。在本研究中，提出了一种非传统的有机催化无溶剂路线，用于环保型的玉米淀粉丙酰化。酰化中使用的催化剂是一种天然存在的α-羟基酸（酒石酸）。获得了取代度（DS）在 0.05-1.59 范围内的丙酰化淀粉，并对其化学结构、形态、结晶度、热稳定性和亲水性进行了表征。结果表明，通过所提出的方法，可以在 2-3 小时的反应时间内获得用于临床应用的所需取代度（即 0.2-0.3）的丙酰化淀粉。表征结果表明，随着取代度的增加，淀粉颗粒的结晶度逐渐降低。
