Kohno M, Murakawa K, Yasunari K, Yokokawa K, Horio T, Kurihara N, Takeda T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Metabolism. 1989 Aug;38(8):712-3. doi: 10.1016/0026-0495(89)90054-1.
The hemodynamic effect of a novel potent vasoconstrictive peptide (endothelin) on systemic blood pressure was studied in bilaterally nephrectomized and sham-operated rats under conscious and almost unrestrained condition. Following bolus IV administration of porcine endothelin, plasma endothelin concentration was measured by radioimmunoassay. After a transient decline, blood pressure was gradually elevated by endothelin administration. At 20, 30, and 40 minutes after injection, blood pressure was significantly elevated in bilaterally nephrectomized rats compared with sham-operated rats. Arterial plasma endothelin concentrations increased and rapidly decreased after injection in both rat groups. Bilateral nephrectomy significantly delayed the disappearance of endothelin from the plasma. These results suggest that the kidney plays a role in the plasma clearance of IV bolus endothelin administration and that the prolonged plasma half-life of endothelin is in part associated with the prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats.
在双侧肾切除和假手术的大鼠处于清醒且几乎无束缚的状态下，研究了一种新型强效血管收缩肽（内皮素）对全身血压的血流动力学效应。静脉推注猪内皮素后，通过放射免疫测定法测量血浆内皮素浓度。在短暂下降后，给予内皮素使血压逐渐升高。注射后20、30和40分钟时，双侧肾切除大鼠的血压与假手术大鼠相比显著升高。两组大鼠注射后动脉血浆内皮素浓度均先升高后迅速下降。双侧肾切除显著延迟了内皮素从血浆中的消失。这些结果表明，肾脏在静脉推注内皮素后的血浆清除中起作用，并且内皮素在血浆中的半衰期延长部分与双侧肾切除大鼠给予内皮素后血压升高时间延长有关。
