蒙古黄芪（膜荚黄芪变种）茎中的齐墩果烷型皂苷

Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.

作者信息

Zhang Yi, Li Xiaoxia, Ruan Jingya, Wang Tingting, Dong Yongzhe, Hao Jia, Liu Erwei, Han Lifeng, Gao Xiumei, Wang Tao

机构信息

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.

出版信息

Fitoterapia. 2016 Mar;109:99-105. doi: 10.1016/j.fitote.2015.12.006. Epub 2015 Dec 11.

DOI:10.1016/j.fitote.2015.12.006

PMID:26687558

Abstract

Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins A (1), B (2), C1 (3), C2 (4), D (5), E1 (6), E2 (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1-5, 7, 8, 11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells.

摘要

黄芪是一种属于豆科的传统中药。在中医临床中，它一直被用作抗糖尿病、心脏保护和肝脏保护药物。从蒙古黄芪（Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao）的茎中，获得了14种齐墩果烷型皂苷（1-14），包括8种新的皂苷，即黄芪皂苷A（1）、B（2）、C1（3）、C2（4）、D（5）、E1（6）、E2（7）和F（8），并通过化学和光谱方法阐明了它们的结构。化合物1-5、7、8、11和13对油酸钠诱导的HepG2细胞中的甘油三酯水平有降低作用。