X染色体失活与逃逸
X-chromosome inactivation and escape.
作者信息
Disteche Christine M, Berletch Joel B
机构信息
Department of Pathology, University of Washington, Seattle,WA 98195, USA.
出版信息
J Genet. 2015 Dec;94(4):591-9. doi: 10.1007/s12041-015-0574-1.
Abstract
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.
摘要
X染色体失活由玛丽·莱昂于1961年发现，它导致雌性哺乳动物的一条X染色体随机沉默。这篇综述是献给去年去世的玛丽·莱昂的。她预测了X染色体失活的许多特征，例如，X染色体失活中心的存在、L1元件在沉默传播中的作用以及逃避X染色体失活的基因的存在。从她发表的作品出发，我们在此总结该领域的进展。
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