Siglec-8和Siglec-9唾液酸聚糖配体表达对气道炎症的调节作用。
Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression.
作者信息
Schleimer Robert P, Schnaar Ronald L, Bochner Bruce S
机构信息
aDivision of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois bDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Curr Opin Allergy Clin Immunol. 2016 Feb;16(1):24-30. doi: 10.1097/ACI.0000000000000234.
PURPOSE OF REVIEW
Inflammatory cells involved in the allergic response, including eosinophils, mast cells, basophils, and neutrophils, express sialoglycan-binding proteins such as Siglec-8 and Siglec-9, which inhibit cell function and survival. The purpose of this review is to briefly discuss the biology of these siglecs and their ligands and consider their potential impact in pathology and treatment of chronic rhinosinusitis (CRS).
RECENT FINDINGS
Recent studies demonstrate the presence of ligands for Siglec-8 and Siglec-9 in sinonasal tissue from patients with CRS as well as healthy patients, suggesting that the immunoregulatory functions of siglecs may be triggered in sinus tissue in health and disease.
SUMMARY
Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa. Therapeutic strategies that activate the anti-inflammatory effects of siglecs may dampen inflammation and disease in CRS patients.
综述目的
参与过敏反应的炎症细胞，包括嗜酸性粒细胞、肥大细胞、嗜碱性粒细胞和中性粒细胞，表达唾液酸聚糖结合蛋白，如唾液酸结合免疫球蛋白样凝集素-8（Siglec-8）和唾液酸结合免疫球蛋白样凝集素-9（Siglec-9），这些蛋白可抑制细胞功能和存活。本综述的目的是简要讨论这些唾液酸结合免疫球蛋白样凝集素及其配体的生物学特性，并探讨它们在慢性鼻-鼻窦炎（CRS）的病理学和治疗中的潜在影响。
最新发现
最近的研究表明，CRS患者以及健康患者的鼻窦组织中存在Siglec-8和Siglec-9的配体，这表明在健康和疾病状态下，鼻窦组织中唾液酸结合免疫球蛋白样凝集素的免疫调节功能可能会被触发。
总结
Siglec-8和Siglec-9的配体可能调节鼻窦黏膜中嗜酸性粒细胞、肥大细胞、中性粒细胞和其他细胞的功能。激活唾液酸结合免疫球蛋白样凝集素抗炎作用的治疗策略可能会减轻CRS患者的炎症和疾病。
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