School of Mathematics and Statistics, F07, University of Sydney, Sydney, NSW 2006, Australia.
Ann Transl Med. 2015 Nov;3(19):287. doi: 10.3978/j.issn.2305-5839.2015.10.45.
Duchenne muscular dystrophy (DMD), an X-linked disorder, is the most common muscular dystrophy with an incidence in boys of about 200 per million births. It presents in early childhood leading to death in early teens. Its relatively high incidence and severity have stimulated many studies from epidemiological to curative. Recent advances in molecular biology have opened up the possibility of carrier identification and potential reduction of the incidence of cases. This paper gives a population genetics model which can be used to predict the reduction in incidence.
杜氏肌营养不良症（DMD）是一种 X 连锁疾病，是最常见的肌肉疾病，在男孩中的发病率约为每百万出生人数的 200 人。它在儿童早期出现，导致青少年早期死亡。其较高的发病率和严重程度促使人们从流行病学角度进行了许多研究，以期找到治疗方法。分子生物学的最新进展为携带者鉴定和潜在的病例发生率降低开辟了可能性。本文提出了一个群体遗传学模型，可用于预测发病率的降低。
