中药注射剂引起过敏反应的体外实验
In vitro experiment of allergic reactions induced by traditional Chinese medicine injections.
作者信息
Kang Rui-xia, You Rong-li, Wang Lei, Lei Lei, Wang Zhong
出版信息
Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2503-7.
Allergic reactions caused by traditional Chinese medicine injections (TCMIs) become a greatest concern in the clinic application safety. The integral animal evaluation method commonly used in the preclinical evaluation for allergic reactions of TCMIs was not sensitive, specific, quick and objective in observation indexes. Therefore, more researchers have paid attention to the in vitro test method for evaluating allergic reactions induced by TCMIs. Currently, the methods for evaluating allergic reactions induced by TCMIs are mainly targeted at type I allergic reaction and anaphylactic reaction, with only a few in vitro methods for evaluating type II allergic reaction. In this paper, researchers summarized relevant literatures published about evaluation methods for allergic reactions induced by TCMIs in recent years.
中药注射剂（TCMIs）引起的过敏反应成为临床应用安全性中最受关注的问题。目前中药注射剂过敏反应临床前评价常用的整体动物评价方法在观察指标上不敏感、不特异、不快速且不客观。因此，越来越多的研究者关注中药注射剂过敏反应的体外评价方法。目前，中药注射剂过敏反应的评价方法主要针对Ⅰ型过敏反应和过敏性反应，而评价Ⅱ型过敏反应的体外方法较少。本文中，研究者总结了近年来发表的有关中药注射剂过敏反应评价方法的相关文献。
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