肌醇可能预防超重女性妊娠期糖尿病的发生：一项随机对照试验。
Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial.
作者信息
Santamaria Angelo, Di Benedetto Antonino, Petrella Elisabetta, Pintaudi Basilio, Corrado Francesco, D'Anna Rosario, Neri Isabella, Facchinetti Fabio
机构信息
a Department of Pediatrics , Gynecology, Microbiology and Biomedical Sciences, University of Messina , Messina , Italy .
b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy , and.
出版信息
J Matern Fetal Neonatal Med. 2016 Oct;29(19):3234-7. doi: 10.3109/14767058.2015.1121478. Epub 2015 Dec 23.
OBJECTIVE
To evaluate whether myo-inositol supplementation may reduce gestational diabetes mellitus (GDM) rate in overweight women.
METHODS
In an open-label, randomized trial, myo-inositol (2 g plus 200 μg folic acid twice a day) or placebo (200 μg folic acid twice a day) was administered from the first trimester to delivery in pregnant overweight non-obese women (pre-pregnancy body mass index ≥ 25 and < 30 kg/m(2)). The primary outcome was the incidence of GDM.
RESULTS
From January 2012 to December 2014, 220 pregnant women were randomized at two Italian University hospitals, 110 to myo-inositol and 110 to placebo. The incidence of GDM was significantly lower in the myo-inositol group compared to the placebo group (11.6% versus 27.4%, respectively, p = 0.004). Myo-inositol treatment was associated with a 67% risk reduction of developing GDM (OR 0.33; 95% CI 0.15-0.70).
CONCLUSIONS
Myo-inositol supplementation, administered since early pregnancy, reduces GDM incidence in overweight non-obese women.
目的
评估补充肌醇是否可降低超重女性患妊娠期糖尿病（GDM）的几率。
方法
在一项开放标签的随机试验中，对怀孕的超重非肥胖女性（孕前体重指数≥25且<30kg/m²）从孕早期至分娩给予肌醇（2g加200μg叶酸，每日两次）或安慰剂（200μg叶酸，每日两次）。主要结局是GDM的发生率。
结果
2012年1月至2014年12月，220名孕妇在两家意大利大学医院被随机分组，110名接受肌醇治疗，110名接受安慰剂治疗。与安慰剂组相比，肌醇组GDM的发生率显著更低（分别为11.6%和27.4%，p = 0.004）。肌醇治疗使发生GDM的风险降低了67%（比值比0.33；95%置信区间0.15 - 0.70）。
结论
从孕早期开始补充肌醇可降低超重非肥胖女性患GDM的发生率。
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