Zebitay A G, Tutumlu M, Verit F F, Ilhan G K, Gungor E S, Cetin O, Vuruşkan E
a Department of Obstetrics and Gynecology , In Vitro Fertilization Unit, Suleymaniye Maternity and Women's Disease Education and Research Hospital , Istanbul , Turkey and.
b Doppler Ultrasonography Unit, Suleymaniye Maternity and Women's Disease Education and Research Hospital , Istanbul , Turkey.
Gynecol Endocrinol. 2016 Jun;32(6):442-5. doi: 10.3109/09513590.2015.1126709. Epub 2015 Dec 24.
We aimed to compare ovarian (O), uterine (U) and spiral (S) artery (A) resistance of patients diagnosed as fertile, unexplained infertility (UI) and tubal factor infertility (TFI) in the peri-implantation period and independent from the impact of the treatment. UI (n = 70), TFI (n = 75) and fertile (n = 72) patients' ovarian, uterine and spiral artery pulsatility index (PI), resistance index (RI) and the endometrial thickness, serum estradiol and progesterone levels were compared. The specificity and sensitivity values were calculated according to determined cutoff values. Both TFI and control groups' UA PI values were significantly lower than the UI group's PI values. The highest UA RI values were found in UI group and the lowest values were in the control group. UI and TFI groups' OA PI/RI values were significantly higher than the control group. Both the control and TFI groups' SA PI/RI values were significantly lower than UI group's PI/RI values. UI patients' uterine and spiral arteries PI values >1.86 and >0.85, RI values >0.80 and >0.53 can be used as a valuable test showing reduced uterine perfusion. Ovarian artery PI values >0.96 and RI values >0.58 can be used as tests showing decreased ovarian perfusion in patients with TFI. In these patients, embryo cryopreservation can be considered.
我们旨在比较确诊为可育、不明原因不孕（UI）和输卵管因素不孕（TFI）的患者在着床期的卵巢（O）、子宫（U）和螺旋（S）动脉（A）阻力，且不受治疗影响。比较了UI组（n = 70）、TFI组（n = 75）和可育组（n = 72）患者的卵巢、子宫和螺旋动脉搏动指数（PI）、阻力指数（RI）以及子宫内膜厚度、血清雌二醇和孕酮水平。根据确定的临界值计算特异性和敏感性值。TFI组和对照组的子宫动脉PI值均显著低于UI组的PI值。UI组的子宫动脉RI值最高，对照组最低。UI组和TFI组的卵巢动脉PI/RI值显著高于对照组。对照组和TFI组的螺旋动脉PI/RI值均显著低于UI组的PI/RI值。UI患者子宫动脉和螺旋动脉PI值>1.86和>0.85、RI值>0.80和>0.53可作为显示子宫灌注减少的有价值检测指标。TFI患者卵巢动脉PI值>0.96和RI值>0.58可作为显示卵巢灌注减少的检测指标。对于这些患者，可考虑胚胎冷冻保存。
