Castellanos-González María, Velasco-Rodríguez Diego, Mancebo Plaza Ana Belén
Servicio de Dermatología y Venereología, Hospital del Sureste, Arganda del Rey , Madrid, España.
Servicio de Hematología y Hemoterapia, Hospital Ramón y Cajal, Madrid, España.
Med Clin (Barc). 2016 May 6;146(9):402-7. doi: 10.1016/j.medcli.2015.10.017. Epub 2015 Dec 14.
Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from other skin manifestations caused by heparin having a worse prognosis and requiring a precise identification.
自2006年佩里诺首次描述了3例与使用肝素相关的出血性大疱患者以来，已有大量病例发表。目前，这一实体已被确立为一种明确界定的病理学现象。我们回顾了所有已报道的病例、诊断特征以及将其与肝素引起的其他皮肤表现相区分的特征，后者预后较差，需要精确识别。
