Jiang Ye, Wang Li, Lao Jie, Zhao Xin
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China.
Department of Hand Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
J Plast Reconstr Aesthet Surg. 2016 May;69(5):623-8. doi: 10.1016/j.bjps.2015.11.004. Epub 2015 Nov 25.
The aim of this study is to compare the treatment outcome of nerve transfer using intercostal nerves (ICNs) or contralateral C7 (cC7) root in rats.
Ninety adult Sprague-Dawley rats were randomly divided into three groups of 30 each: group A (cC7 root transfer), group B (ICNs transfer), and group C (control). Electrophysiological examination, muscle tension test, neuromorphology, and muscle fiber cross-sectional area measurements obtained from the three groups were compared to evaluate neurotization outcome 4, 8, and 12 weeks postoperatively.
Median nerve regeneration and the flexor digitorum superficialis (FDS) muscle functional recovery of group B were worse than group A from comparison of both groups' parameters.
Neurotization of ICNs to the lower trunk is difficult to replace cC7 root transfer to the median nerve for restoration of hand function in total brachial plexus injury (BPI). Therefore, at present, the more important implication of the comparative study is that traditional cC7 root transfer remains the mainstay strategy to repair forearm flexor muscle function.
本研究旨在比较在大鼠中使用肋间神经（ICNs）或对侧C7（cC7）神经根进行神经移植的治疗效果。
将90只成年Sprague-Dawley大鼠随机分为三组，每组30只：A组（cC7神经根移植）、B组（ICNs移植）和C组（对照组）。比较三组术后4周、8周和12周的电生理检查、肌张力测试、神经形态学和肌肉纤维横截面积测量结果，以评估神经再生结果。
通过比较两组参数，B组的正中神经再生和指浅屈肌（FDS）肌肉功能恢复比A组差。
在全臂丛神经损伤（BPI）中，肋间神经向臂丛下干的神经再生难以替代cC7神经根移植至正中神经来恢复手部功能。因此，目前该对比研究更重要的意义在于，传统的cC7神经根移植仍是修复前臂屈肌功能的主要策略。
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