Taborda A, Benabdallah N, Desbrée A
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SDI/LEDI, BP-17, 31, Avenue de la Division Leclerc, 92262 Fontenay-aux-Roses, France.
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM/SDI/LEDI, BP-17, 31, Avenue de la Division Leclerc, 92262 Fontenay-aux-Roses, France.
Appl Radiat Isot. 2016 Feb;108:58-63. doi: 10.1016/j.apradiso.2015.12.010. Epub 2015 Dec 9.
The Auger-electrons emitted by (99m)Tc have been recently associated with the induction of thyroid stunning in in vivo experiments in mice, making the dosimetry at the sub-cellular level of (99m)Tc a pertinent and pressing subject. The S-values for (99m)Tc were calculated using MCNP6, which was first validated for studies at the sub-cellular scale and for low energies electrons. The calculation was then performed for (99m)Tc within different cellular compartments in a single mouse thyroid follicle model, considering the radiative and non-radiative transitions of the (99m)Tc radiation spectrum. It was shown that the contribution of the (99m)Tc Auger and low energy electrons to the absorbed dose to the follicular cells' nucleus is important, being at least of the same order of magnitude compared to the emitted photons' contribution and cannot be neglected. The results suggest that Auger-electrons emitted by (99m)Tc play a significant role in the occurrence of the thyroid stunning effect in mice.
最近在小鼠体内实验中发现，（99m）Tc发射的俄歇电子与甲状腺顿抑的诱导有关，这使得（99m）Tc亚细胞水平的剂量学成为一个相关且紧迫的课题。使用MCNP6计算了（99m）Tc的S值，该软件首先在亚细胞尺度和低能电子研究中得到验证。然后在单个小鼠甲状腺滤泡模型的不同细胞区室中对（99m）Tc进行计算，考虑（99m）Tc辐射光谱的辐射和非辐射跃迁。结果表明，（99m）Tc俄歇电子和低能电子对滤泡细胞核吸收剂量的贡献很重要，与发射光子的贡献相比至少处于同一数量级，不能忽略。结果表明，（99m）Tc发射的俄歇电子在小鼠甲状腺顿抑效应的发生中起重要作用。
Zotero 插件