[宫颈癌发生发展过程中Twist和YB-1上调与上皮-间质转化的相关性]
[Correlation of Twist and YB-1 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma].
作者信息
Li Min, Guan Hong, Hu Xinrong, Wang Ying, Wei Qian, Yang Qingfeng
机构信息
Department of Pathology, Longhua New District People's Hospital, Shenzhen 518109, China.
Cancer Institute, Guangdong Medical University, Dongguan 523808, China; E-mail:
出版信息
Zhonghua Bing Li Xue Za Zhi. 2015 Aug;44(8):594-9.
OBJECTIVE
To investigate the clinicopathological significance of Twist and YB-1 up-regulation in cervical cancer, and to correlate the expression of the two genes with E-cadherin, a marker of epithelial-mesenchymal transition (EMT).
METHODS
A total of 202 tissue samples were collected during January 2008 to December 2013, including 50 cases of normal cervical tissues, 100 cases of cervical intraepithelial neoplasia (CIN) and 52 cases of squamous cell carcinoma (SCC). Twist, YB-1 and E-cadherin expression was investigated by MaxVision.
RESULTS
Increased expression levels of Twist and YB-1 were found and correlated with the malignant transformation of cervical epithelium, histological progression and metastasis of cervical cancer. In addition, Twist and YB-1 overexpression was also associated with aberrant expression of E-cadherin. Regression analysis revealed that Twist expression was an independent factor for the histological progression of cervical cancer.
CONCLUSIONS
It is suggested that Twist and YB-1 overexpression is significantly linked to cervical cancer tumorigenesis and progression, likely related to EMT through (YB-1)-Twist-(E-cadherin) pathway. Twist and YB-1 may be markers for determining the metastatic potential of cervical cancer.
目的
探讨Twist和YB-1上调在宫颈癌中的临床病理意义，并将这两个基因的表达与上皮-间质转化（EMT）的标志物E-钙黏蛋白相关联。
方法
收集2008年1月至2013年12月期间的202份组织样本，包括50例正常宫颈组织、100例宫颈上皮内瘤变（CIN）和52例鳞状细胞癌（SCC）。采用MaxVision法检测Twist、YB-1和E-钙黏蛋白的表达。
结果
发现Twist和YB-1的表达水平升高，且与宫颈上皮的恶性转化、宫颈癌的组织学进展和转移相关。此外，Twist和YB-1的过表达还与E-钙黏蛋白的异常表达有关。回归分析显示，Twist表达是宫颈癌组织学进展的独立因素。
结论
提示Twist和YB-1过表达与宫颈癌的发生和进展密切相关，可能通过（YB-1）-Twist-（E-钙黏蛋白）途径与EMT相关。Twist和YB-1可能是判断宫颈癌转移潜能的标志物。
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