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p53 coordinates with Δ133p53 isoform to promote cell survival under low-level oxidative stress.p53与Δ133p53异构体协同作用，以促进低水平氧化应激下的细胞存活。
J Mol Cell Biol. 2016 Feb;8(1):88-90. doi: 10.1093/jmcb/mjv069. Epub 2015 Dec 23.
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Functional interplay between p53 and Δ133p53 in adaptive stress response.p53 与 Δ133p53 在适应应激反应中的功能相互作用。
Cell Death Differ. 2020 May;27(5):1618-1632. doi: 10.1038/s41418-019-0445-z. Epub 2019 Oct 28.
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Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish.p53 异构体 Δ113p53 的失活功能加速斑马鱼的大脑衰老。
Cell Death Dis. 2021 Feb 4;12(2):151. doi: 10.1038/s41419-021-03438-9.
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Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript.Δ160p53 是一种新型的 N 端 p53 异构体，由 Δ133p53 转录本编码。
FEBS Lett. 2010 Nov 5;584(21):4463-8. doi: 10.1016/j.febslet.2010.10.005. Epub 2010 Oct 13.
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Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence.氧化还原调控与 p53 异构体间的相互作用：在调节基础 p53 水平、细胞命运和衰老中的作用。
Antioxid Redox Signal. 2011 Sep 15;15(6):1655-67. doi: 10.1089/ars.2010.3771. Epub 2011 May 4.
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Δ113p53/Δ133p53: survival and integrity.Δ113p53/Δ133p53：生存与完整性。
Oncotarget. 2015 Jun 10;6(16):13850-1. doi: 10.18632/oncotarget.4371.
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Δ133p53 coordinates ECM-driven morphogenesis and gene expression in three-dimensional mammary epithelial acini.Δ133p53 协调 ECM 驱动的三维乳腺上皮细胞小球形态发生和基因表达。
J Cell Sci. 2022 Nov 1;135(21). doi: 10.1242/jcs.259673. Epub 2022 Nov 4.
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A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation.Δ133p53 异构体的小鼠模型：在癌症进展和炎症中的作用。
Mamm Genome. 2018 Dec;29(11-12):831-842. doi: 10.1007/s00335-018-9758-3. Epub 2018 Jul 10.
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CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop.CUL4B 通过抑制 p53-活性氧正向反馈环来阻碍应激诱导的细胞衰老。
Free Radic Biol Med. 2015 Feb;79:1-13. doi: 10.1016/j.freeradbiomed.2014.11.010. Epub 2014 Nov 21.
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Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species.突变型 p53R273H 减弱了Ⅱ相解毒酶的表达，并促进了高活性氧水平的细胞存活。
J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86. doi: 10.1242/jcs.106815. Epub 2012 Aug 16.
引用本文的文献
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Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation.肿瘤抑制蛋白p53的Δ133p53α和Δ160p53α亚型主要通过共聚集发挥显性负效应。
Elife. 2025 Jul 21;14:RP106469. doi: 10.7554/eLife.106469.
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Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis.Wdr5介导的H3K4me3协同调节消化器官发生过程中的细胞分化、增殖终止和存活。
Cell Death Discov. 2023 Jul 5;9(1):227. doi: 10.1038/s41420-023-01529-4.
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The Underestimated Role of the p53 Pathway in Renal Cancer.p53通路在肾癌中被低估的作用
Cancers (Basel). 2022 Nov 22;14(23):5733. doi: 10.3390/cancers14235733.
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p53 and Its Isoforms in Renal Cell Carcinoma-Do They Matter?肾细胞癌中的p53及其异构体——它们重要吗？
Biomedicines. 2022 Jun 6;10(6):1330. doi: 10.3390/biomedicines10061330.
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Adaptive homeostasis and the p53 isoform network.自适应稳态和 p53 异构体网络。
EMBO Rep. 2021 Dec 6;22(12):e53085. doi: 10.15252/embr.202153085. Epub 2021 Nov 15.
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Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish.p53 异构体 Δ113p53 的失活功能加速斑马鱼的大脑衰老。
Cell Death Dis. 2021 Feb 4;12(2):151. doi: 10.1038/s41419-021-03438-9.
7
The Δ133p53 Isoforms, Tuners of the p53 Pathway.Δ133p53 异构体，p53 通路的调节因子。
Cancers (Basel). 2020 Nov 18;12(11):3422. doi: 10.3390/cancers12113422.
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p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis.p53 异构体Δ113p53 通过维持氧化还原稳态促进斑马鱼心脏再生。
Cell Death Dis. 2020 Jul 23;11(7):568. doi: 10.1038/s41419-020-02781-7.
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p53 and its isoforms in DNA double-stranded break repair.p53 及其异构体在 DNA 双链断裂修复中的作用。
J Zhejiang Univ Sci B. 2019 Jun;20(6):457-466. doi: 10.1631/jzus.B1900167.
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A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation.Δ133p53 和 ΔNp63 之间的功能相互作用促进糖酵解代谢以促进癌细胞增殖。
Oncogene. 2018 Apr;37(16):2150-2164. doi: 10.1038/s41388-017-0117-8. Epub 2018 Jan 26.
本文引用的文献
1
p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage.p53 异构体Δ113p53/Δ133p53促进DNA双链断裂修复，以保护细胞免受DNA损伤诱导的死亡和衰老。
Cell Res. 2015 Mar;25(3):351-69. doi: 10.1038/cr.2015.22. Epub 2015 Feb 20.
2
Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence.氧化还原调控与 p53 异构体间的相互作用：在调节基础 p53 水平、细胞命运和衰老中的作用。
Antioxid Redox Signal. 2011 Sep 15;15(6):1655-67. doi: 10.1089/ars.2010.3771. Epub 2011 May 4.
3
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production.p53 与肿瘤抑制和致癌信号通路相互作用，以控制细胞内活性氧的产生。
Antioxid Redox Signal. 2011 Sep 15;15(6):1749-61. doi: 10.1089/ars.2010.3652. Epub 2011 Apr 14.
4
p53, ROS and senescence in the control of aging.p53、活性氧与衰老调控中的细胞衰老
Aging (Albany NY). 2010 Aug;2(8):471-4. doi: 10.18632/aging.100189.
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p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage.p53 直接反式激活 Δ133p53α，调控细胞命运对 DNA 损伤的应答。
Cell Death Differ. 2011 Feb;18(2):248-58. doi: 10.1038/cdd.2010.91. Epub 2010 Aug 6.
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p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter.p53 通过其 Delta133p53 异构体中包含的特定反应元件调节 TP53 P2 内部启动子的转录。
Oncogene. 2010 May 6;29(18):2691-700. doi: 10.1038/onc.2010.26. Epub 2010 Mar 1.
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Reactive oxygen species-dependent signaling regulates cancer.活性氧物种依赖性信号传导调控癌症。
Cell Mol Life Sci. 2009 Dec;66(23):3663-73. doi: 10.1007/s00018-009-0099-y. Epub 2009 Jul 24.
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p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.p53 异构体 delta113p53 是一种 p53 靶基因，其在斑马鱼中通过激活 BclxL 拮抗 p53 的凋亡活性。
Genes Dev. 2009 Feb 1;23(3):278-90. doi: 10.1101/gad.1761609.
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p53 isoforms can regulate p53 transcriptional activity.p53 异构体可调节 p53 的转录活性。
Genes Dev. 2005 Sep 15;19(18):2122-37. doi: 10.1101/gad.1339905. Epub 2005 Aug 30.
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