[输血相关移植物抗宿主病的发病机制与预防]

[Pathogenesis and Prevention of Transfusion-Associated Graft-versus-Host Disease].

作者信息

Feng Fei-Er, Wang Qian-Ming, Zhu Xiao-Lu, Wang Chen-Cong, Zhang Xiao-Hui

机构信息

Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China. E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Dec;23(6):1774-9. doi: 10.7534/j.issn.1009-2137.2015.06.044.

DOI:10.7534/j.issn.1009-2137.2015.06.044

PMID:26708909

Abstract

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare complication of blood transfusion. The disease is fulminant and fatal in most patients. TA-GVHD is caused by transfused alloreactive donor T lymphocytes that attack host tissue, including skin, liver, gastrointestinal tract and bone marrow. Most patients are immunocompromised, but immunocompetent patients can also be involved. Irradiation of blood components is generally recommended to prevent the onset of TA-GVHD for susceptible recipients. This review focus on pathogenesis and prevention of TA-GVHD.

摘要

输血相关移植物抗宿主病（TA-GVHD）是一种罕见的输血并发症。该病在大多数患者中呈暴发性且致命。TA-GVHD是由输注的同种异体反应性供体T淋巴细胞攻击宿主组织（包括皮肤、肝脏、胃肠道和骨髓）引起的。大多数患者免疫功能低下，但免疫功能正常的患者也可能受累。一般建议对易感受者进行血液成分辐照以预防TA-GVHD的发生。本综述聚焦于TA-GVHD的发病机制及预防。