Jawa Randeep S, Young David H, Stothert Joseph C, Kulaylat Mahmoud N, Landmark James D
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
J Intensive Care Med. 2015 Mar;30(3):123-30. doi: 10.1177/0885066613492645. Epub 2013 Jun 20.
Transfusion associated-graft versus host disease (TA-GVHD) is a rare complication of blood transfusion. It carries a very high mortality rate. Although the phenomenon has been well described in immunocompromised patients, this review focuses on the immunocompetent host. Cases of TA-GVHD continue to be reported following a variety of surgical procedures, especially cardiac procedures requiring cardiopulmonary bypass. Additional risk factors for TA-GVHD include blood component transfusion in populations with limited genetic diversity, the use of directed donations from family members, and the transfusion of fresh blood. As there is no effective treatment, the focus is on prevention.
输血相关移植物抗宿主病（TA-GVHD）是一种罕见的输血并发症。它的死亡率非常高。尽管这种现象在免疫功能低下的患者中已有详细描述，但本综述聚焦于免疫功能正常的宿主。在各种外科手术之后，尤其是需要体外循环的心脏手术之后，仍不断有TA-GVHD病例被报道。TA-GVHD的其他风险因素包括在遗传多样性有限的人群中进行血液成分输血、使用家庭成员的定向捐赠血液以及输注新鲜血液。由于没有有效的治疗方法，重点在于预防。
