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非流行地区“妊娠、黑热病和噬血细胞性淋巴组织细胞增生症”的独特三联征

Unique Triad of 'Pregnancy, Kala Azar and Hemophagocytic Lymphohistiocytic Syndrome from a Non-Endemic Region'.

作者信息

Pawar Satyajit, Ragesh R, Nischal Neeraj, Sharma Sanchit, Panda Prasan Kumar, Sharma S K

出版信息

J Assoc Physicians India. 2015 Jun;63(6):65-8.

PMID:26710404
Abstract

India and neighboring Nepal, Bangladesh along with Sudan and Brazil are the four largest foci of visceral leishmaniasis and account for 90% of the world's visceral leishmaniasis (VL) burden, with India being the worst affected. High degree of suspicion is usually based on patient presenting from endemic area with features of pancytopenia hepatosplenomegaly. Hemophagocytic lymphohistiocytic (HLH) syndrome also presents with similar clinical features. Visceral leishmaniasis leading to secondary HLH syndrome is in itself a rare entity while both of these presenting in pregnant patient, to the best knowledge of the authors, is yet to be described in literature.

摘要

印度及其邻国尼泊尔、孟加拉国以及苏丹和巴西是内脏利什曼病的四大主要疫源地,占全球内脏利什曼病负担的90%,其中印度受影响最为严重。高度怀疑通常基于来自流行地区且有全血细胞减少、肝脾肿大特征的患者。噬血细胞性淋巴组织细胞增生症(HLH)综合征也有类似的临床特征。导致继发性HLH综合征的内脏利什曼病本身是一种罕见疾病,而就作者所知,这两种疾病同时出现在孕妇身上的情况在文献中尚未有描述。

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引用本文的文献

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Am J Trop Med Hyg. 2022 Nov 14;107(6):1203-1209. doi: 10.4269/ajtmh.22-0361. Print 2022 Dec 14.
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Visceral Leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans.妊娠合并内脏利什曼病和垂直传播:治疗孤儿的系统文献综述。
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Rising visceral leishmaniasis in Holy Himalayas (Uttarakhand, India) - A cross-sectional hospital-based study.
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J Family Med Prim Care. 2020 Mar 26;9(3):1362-1369. doi: 10.4103/jfmpc.jfmpc_1174_19. eCollection 2020 Mar.
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Hemophagocytic lymphohistiocytosis in the setting of HELLP Syndrome.HELLP综合征背景下的噬血细胞性淋巴组织细胞增生症。
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