Kemal Y, Demirag G, Teker F, Kut E, Kefeli M, Ekiz K, Yucel I
Samsun Education and Research Hospital, Department of Medical Oncology, Samsun 55100, Turkey.
19 Mayis University, Faculty of Medicine, Department of Medical Oncology, Samsun 55270, Turkey.
Exp Oncol. 2015 Dec;37(4):281-4.
Breast cancer (BC) is the most common cancer among women. A high body-mass index (BMI) is related to increased incidence of BC with poorer prognosis.
The aim of the study was to evaluate the association in patients with BC between BMI at the time of diagnosis and biological characteristics, according to the menopausal status.
This retrospective study comprised a total of 318 women with BC. Clinicopathological differences between normal, overweight and obese patients according to menopausal status were evaluated.
Premenopausal women had a significantly lower BMI than postmenopausal patients (28.7 vs. 31.5, respectively; p = 0.00001). No statistically significant association was determined between BMI and clinicopathological characteristics in either the premenopausal or the postmenopausal group (all p values are > 0.05).
There are many conflicting results in literature on this relationship. The results of this study showed that a high BMI is not associated with worse clinicopathological characteristics in a predominantly obese population. In current medical oncology practice, BC should be evaluated on an individual patient basis and the impact of obesity on BC prognosis seems to be difficult to estimate especially in an obese population.
乳腺癌（BC）是女性中最常见的癌症。高体重指数（BMI）与BC发病率增加及预后较差有关。
本研究的目的是根据绝经状态评估BC患者诊断时的BMI与生物学特征之间的关联。
这项回顾性研究共纳入318例BC女性患者。根据绝经状态评估正常、超重和肥胖患者之间的临床病理差异。
绝经前女性的BMI显著低于绝经后患者（分别为28.7和31.5；p = 0.00001）。绝经前或绝经后组中，BMI与临床病理特征之间均未确定有统计学意义的关联（所有p值均>0.05）。
关于这种关系，文献中有许多相互矛盾的结果。本研究结果表明，在以肥胖为主的人群中，高BMI与较差的临床病理特征无关。在当前医学肿瘤学实践中，应根据个体患者情况评估BC，肥胖对BC预后的影响似乎难以估计，尤其是在肥胖人群中。
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