Hasan Razan, Abdalla Nader, Bilal Maram
Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
Department of Oncology, Faculty of Medicine, Tishreen University, Lattakia, Syria.
Ann Med Surg (Lond). 2025 May 29;87(7):4034-4038. doi: 10.1097/MS9.0000000000003371. eCollection 2025 Jul.
Breast cancer is the most common cancer between females globally with many involving risk factors. There are increasing evidences about the role of obesity, which is usually assessed using body mass index (BMI), and hypercholesterolemia in breast cancer development through different mechanisms including the interplay with the immune response. The histopathological grading, which reflects the degree of differentiation, could be used to determine the aggressiveness of breast cancer. Limited studies assessed the correlation between the previous factors and histopathological grading in breast cancer patients and they concluded controversial results.
We aimed to investigate the correlation of BMI and total cholesterol levels with histopathological grading in breast cancer patients with regard to menopausal status.
Total cholesterol was measured using Qimica kit/Spain and data were analyzed using suitable statistical tests. -value<0.05 was considered as statistically significant.
We found a significant relationship between BMI and tumor grading ( = 0.008). The correlation was observed in postmenopausal patients ( = 0.01) with no correlation in premenopausal patients ( = 0.32). Also, there was a significant correlation between total cholesterol and tumor grading ( = 0.003) only in postmenopausal patients ( = 0.011) with no correlation in premenopausal patients ( = 0.32).
There is a significant relationship of histopathological grading with both BMI and total cholesterol levels in postmenopausal breast cancer patients. Further studies with larger samples are needed to evaluate the role of those factors in breast cancer progression and aggressiveness and their effects on immunotherapy tolerance and response.
乳腺癌是全球女性中最常见的癌症，涉及多种风险因素。越来越多的证据表明肥胖（通常用体重指数（BMI）评估）和高胆固醇血症通过不同机制（包括与免疫反应的相互作用）在乳腺癌发生发展中发挥作用。组织病理学分级反映了分化程度，可用于确定乳腺癌的侵袭性。有限的研究评估了上述因素与乳腺癌患者组织病理学分级之间的相关性，得出了有争议的结果。
我们旨在研究乳腺癌患者中BMI和总胆固醇水平与组织病理学分级之间的相关性，并考虑绝经状态。
使用西班牙Qimica试剂盒测量总胆固醇，并使用适当的统计检验分析数据。P值<0.05被认为具有统计学意义。
我们发现BMI与肿瘤分级之间存在显著关系（P = 0.008）。这种相关性在绝经后患者中观察到（P = 0.01），而在绝经前患者中无相关性（P = 0.32）。此外，总胆固醇与肿瘤分级之间仅在绝经后患者中存在显著相关性（P = 0.003）（P = 0.011），在绝经前患者中无相关性（P = 0.32）。
绝经后乳腺癌患者的组织病理学分级与BMI和总胆固醇水平均存在显著关系。需要进一步进行更大样本量的研究，以评估这些因素在乳腺癌进展和侵袭性中的作用及其对免疫治疗耐受性和反应的影响。
