鸭和鸡中2.3.4.4分支高致病性H5禽流感病毒的特征分析
Characterization of clade 2.3.4.4 highly pathogenic H5 avian influenza viruses in ducks and chickens.
作者信息
Sun Honglei, Pu Juan, Hu Jiao, Liu Litao, Xu Guanlong, Gao George F, Liu Xiufan, Liu Jinhua
机构信息
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.
Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
出版信息
Vet Microbiol. 2016;182:116-22. doi: 10.1016/j.vetmic.2015.11.001. Epub 2015 Nov 10.
Worldwide dissemination of reassortant variants of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses has posed a great threat to the poultry industry. Here, we systematically characterized the H5N2, H5N6 and H5N8 influenza viruses in poultry and compared them with those of previous clade 2.3.4 H5N1 virus. All the three H5 subtype reassortants caused systematic infection in ducks, and exhibited efficient direct transmission in ducks. All of them were highly pathogenic in chickens; however, the H5 reassortants have reduced virulence compared to the parental H5N1 virus. Antigenicity analysis revealed that the current vaccines that are widely used in China may fail to confer protection against the H5 reassortants.
H5进化分支2.3.4.4高致病性禽流感（HPAI）病毒重组变体在全球范围内的传播对家禽业构成了巨大威胁。在此，我们系统地表征了家禽中的H5N2、H5N6和H5N8流感病毒，并将它们与先前进化分支2.3.4的H5N1病毒进行了比较。所有这三种H5亚型重组体在鸭中引起系统性感染，并在鸭中表现出高效的直接传播。它们在鸡中均具有高致病性；然而，与亲本H5N1病毒相比，H5重组体的毒力有所降低。抗原性分析表明，目前在中国广泛使用的疫苗可能无法对H5重组体提供保护。
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