Lu Yi, Li Yue, Li Fenglong, Jiang Chunyan
Department of Orthopedics&Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China.
Department of Orthopedics&Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China; Email:
Zhonghua Yi Xue Za Zhi. 2015 Aug 4;95(29):2337-41.
To compare the effectiveness and safety of ibuprofen, celecoxib and flurbiprofen axetil after arthroscopic rotator cuff repair.
From Dec., 2012 to Dec., 2012, 63 arthroscopy rotator cuff repaired patients in Department of Orthopedics&Traumatology, Beijing Jishuitan Hospital, were selected and divided randomized into 3 groups:flurbiprofen axetil, ibuprofen and celecoxib. Each group had 21 patients. All groups take drugs 5 days continuously after operation. In first five days postoperatively, visual analogue scale (VAS) was used to compare pain alleviation. The side effects were assessed among three groups. VAS, Shoulder evaluation functional score, range of shoulder forward elevation, external rotation and internal rotation were recorded, compared between the same patients preoperatively and postoperatively and compared also among three groups.
Pain was relieved postoperatively with time being in all patients. From 4 day postoperatively, flurbiprofen axetil showed significant difference on pain relieving compared with ibuprofen and celecoxib (P<0.05). Side effects of ibuprofen, celecoxib and flurbiprofen axetil was 33.3%, 14.3% and 9.5% separately. No significant difference was found among three groups. Preoperatively, VAS=7.2, SST=6.5, Constant=67.6, UCLA=17; FE=132.6°, ER=37.7°, IR=L1on average. One year postoperatively, in ibuprofen, celecoxib and flurbiprofen axetil group, VAS was 2.0, 2.1, 1.9; SST was 9.2, 8.5, 10.5; Constant was 82.7, 91.2, 90.5; UCLA was 29.9, 33.2, 30.3; FE was 151.2°, 150.0°, 160.3°, ER was 49.2°, 50.7°, 56.7°; IR was ip to T12, T12, T8 level separately. All patients showed significant improvement on VAS, function evaluation score and range of motion one year postoperatively and no significant difference were found among three groups.
Flurbiprofen axetil showed better result compared with ibuprofen and celecoxib on pain control, although all three COX inhibitors are highly-efficient and safe for rotator cuff repaired patients. There is no significant difference among three groups according to side effects and no delayed on tendon healing.
比较布洛芬、塞来昔布和氟比洛芬酯在关节镜下肩袖修复术后的有效性和安全性。
选取2012年12月至2012年12月在北京积水潭医院创伤骨科行关节镜下肩袖修复术的63例患者，随机分为3组：氟比洛芬酯组、布洛芬组和塞来昔布组，每组21例。所有组术后连续服药5天。术后前5天，采用视觉模拟评分法（VAS）比较疼痛缓解情况。评估三组的副作用。记录VAS、肩关节功能评估评分、肩关节前屈上举、外旋和内旋活动范围，在同一患者术前和术后进行比较，并在三组之间进行比较。
所有患者术后疼痛均随时间缓解。术后第4天起，氟比洛芬酯在缓解疼痛方面与布洛芬和塞来昔布相比有显著差异（P<0.05）。布洛芬、塞来昔布和氟比洛芬酯的副作用分别为33.3%、14.3%和9.5%。三组之间未发现显著差异。术前，平均VAS=7.2，SST=6.5，Constant=67.6，UCLA=17；FE=132.6°，ER=37.7°，IR=L1。术后1年，在布洛芬组、塞来昔布组和氟比洛芬酯组中，VAS分别为2.0、2.1、1.9；SST分别为9.2、8.5、10.5；Constant分别为82.7、91.2、90.5；UCLA分别为29.9、33.2、30.3；FE分别为151.2°、150.0°、160.3°，ER分别为49.2°、50.7°、56.7°；IR分别达到T12、T12、T8水平。所有患者术后1年VAS、功能评估评分和活动范围均有显著改善，三组之间未发现显著差异。
尽管三种环氧化酶抑制剂对肩袖修复患者均高效且安全，但氟比洛芬酯在控制疼痛方面比布洛芬和塞来昔布效果更好。三组在副作用方面无显著差异，且对肌腱愈合无延迟作用。
