细胞核中的Notch信号传导：类主调控分子（MAML）转录共激活因子的作用。
Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators.
作者信息
Kitagawa Motoo
机构信息
Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8670, Japan
出版信息
J Biochem. 2016 Mar;159(3):287-94. doi: 10.1093/jb/mvv123. Epub 2015 Dec 28.
Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
Notch信号通路在所有后生动物物种的发育和体内平衡中起着关键作用。Notch是一种受体分子，可将细胞间接触的信息直接转化为细胞核中的基因表达。Mastermind是一种保守且必需的核因子，可支持Notch的活性。在此，我们综述了过去和当前关于这些因子之间相互作用的研究。
Zotero 插件