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细胞核中的Notch信号传导：类主调控分子（MAML）转录共激活因子的作用。

Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators.

作者信息

Kitagawa Motoo

机构信息

Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-Ku, Chiba 260-8670, Japan

出版信息

J Biochem. 2016 Mar;159(3):287-94. doi: 10.1093/jb/mvv123. Epub 2015 Dec 28.

DOI:10.1093/jb/mvv123
PMID:26711237
Abstract

Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.

摘要

Notch信号通路在所有后生动物物种的发育和体内平衡中起着关键作用。Notch是一种受体分子，可将细胞间接触的信息直接转化为细胞核中的基因表达。Mastermind是一种保守且必需的核因子，可支持Notch的活性。在此，我们综述了过去和当前关于这些因子之间相互作用的研究。

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Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators.细胞核中的Notch信号传导：类主调控分子（MAML）转录共激活因子的作用。
J Biochem. 2016 Mar;159(3):287-94. doi: 10.1093/jb/mvv123. Epub 2015 Dec 28.
2
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Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind.活细胞成像揭示共激活因子 Mastermind 赋予 Notch 转录枢纽记忆和随机激活的动态模式。
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