Zhang Xiangchun, Wang Yanlei, Yan Wei, Mao Jiajia, Wang Jiayong, Jiang Jinbo, Dai Yong
Department of Colorectal Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Department of Colorectal Surgery, Qilu Hospital of Shandong University, Jinan 250012, China; Email:
Zhonghua Yi Xue Za Zhi. 2015 Aug 25;95(32):2612-5.
To investigate the value of lymph node labeled with carbon nanoparticles in laparoscopic colorectal cancer resection.
The clinical data of 53 patients received laparoscopic radical colorectal surgeries in our department from March 2014 to July 2014 was retrospectively analyzed.Among these patients, carbon nanoparticles were injected into the periphery of the tumor under colonoscopy 1-3 days before the operation (the nanoparticle group) in 26 patients, while 27 patients received operation directly (the control group).The number of cleared lymph nodes, tiny lymph nodes (<5 mm), dyed lymph nodes, and lymph node metastatic rate were compared between the two groups.
The two groups had no statistical difference in basic characteristics; 434 and 340 lymph nodes were dissected in the nanoparticle group and control group respectively.The average number of cleared lymph nodes(16.7 ± 3.2) in the nanoparticle group was significantly higher than that of the control group(12.6 ± 2.3) (P<0.001). Besides, both the average number and ratio of cleared tiny lymph nodes in the nanoparticle group were significant higher than those of the control group (P<0.001). Moreover, the rate of less than 12 detected lymph nodes in the nanoparticle group was markedly lower than that of the control group (0 vs 33.3%, P=0.001).There was no statistical difference in lymph node metastatic rate between the two groups (P=0.693).
Application of lymph node labeled with carbon nanoparticles in laparoscopic colorectal cancer surgery could instruct lymph nodes dissection, improve lymph node detection rate, reduce tumor residual rate, improve the accuracy of pathological staging, and guide the postoperative adjuvant therapy.
探讨碳纳米颗粒标记淋巴结在腹腔镜结直肠癌切除术中的价值。
回顾性分析2014年3月至2014年7月在我科接受腹腔镜结直肠癌根治术的53例患者的临床资料。其中，26例患者在术前1 - 3天经结肠镜在肿瘤周边注射碳纳米颗粒（纳米颗粒组），27例患者直接接受手术（对照组）。比较两组清扫淋巴结数目、微小淋巴结（<5 mm）、染色淋巴结及淋巴结转移率。
两组基本特征无统计学差异；纳米颗粒组和对照组分别清扫淋巴结434枚和340枚。纳米颗粒组平均清扫淋巴结数目（16.7±3.2）显著高于对照组（12.6±2.3）（P<0.001）。此外，纳米颗粒组清扫微小淋巴结的平均数目及比例均显著高于对照组（P<0.001）。而且，纳米颗粒组检测淋巴结少于12枚的比例明显低于对照组（0 vs 33.3%，P = 0.001）。两组淋巴结转移率无统计学差异（P = 0.693）。
碳纳米颗粒标记淋巴结应用于腹腔镜结直肠癌手术可指导淋巴结清扫，提高淋巴结检出率，降低肿瘤残留率，提高病理分期准确性，并指导术后辅助治疗。
