Alsaied Tarek, Goldstein Stuart L, Kaddourah Ahmad, Poynter Sue E
Pediatric Residency Training Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Pediatr Int. 2016 Mar;58(3):232-234. doi: 10.1111/ped.12780. Epub 2015 Dec 29.
Thrombocytopenia-associated multi-organ failure (TAMOF) is an increasingly reported entity in the pediatric intensive care unit. The clinical presentation is similar to thrombotic thrombocytopenic purpura, but with no evidence of hemolysis and no schistocytes on peripheral smear. We report a case of TAMOF induced by diabetic ketoacidosis and treated with therapeutic plasma exchange (TPE). Early diagnosis and initiation of TPE significantly decrease the morbidity associated with TAMOF.
血小板减少相关多器官功能衰竭（TAMOF）是儿科重症监护病房中报告日益增多的一种病症。其临床表现与血栓性血小板减少性紫癜相似，但外周血涂片无溶血证据且无裂红细胞。我们报告1例由糖尿病酮症酸中毒诱发并接受治疗性血浆置换（TPE）的TAMOF病例。早期诊断并启动TPE可显著降低与TAMOF相关的发病率。
