Sun A, Wu Y C
Taiwan Yi Xue Hui Za Zhi. 1989 Feb;88(2):122-7.
Using indirect immunofluorescent antibody technique, anti-mucosal antibodies were evaluated in single or sequentially multiple sera from 21 patients with recurrent aphthous ulcers (RAU), 41 age/sex-matched healthy subjects, and 40 patients with miscellaneous oral mucosal diseases. Although anti-mucosal antibodies were found widely distributed in patients having oral mucosal diseases, there were significantly higher rates of positive anti-mucosal antibodies (15/21, 71%) and circulating intercellular substance (ICS) antibodies (14/21, 67%) in RAU patients as compared with either the healthy subjects or patients with miscellaneous oral mucosal diseases. Circulating ICS antibodies of IgG class were found to be significantly predominant in the active phase of 67% (14/21) RAU patients. The percentage decreased in the order of 25% (4/16) in the remission phase of one week, and to 10% (1/10) in the remission phase of two weeks. The presence of pemphigus-like antibodies might be elicited by the epidermal occult antigens released from damaged tissue and/or due to the transient immunoregulatory dysfunction caused by certain infectious agents.
采用间接免疫荧光抗体技术，对21例复发性阿弗他溃疡（RAU）患者、41例年龄/性别匹配的健康受试者以及40例患有其他口腔黏膜疾病的患者的单份血清或连续多份血清中的抗黏膜抗体进行了评估。虽然在患有口腔黏膜疾病的患者中广泛发现了抗黏膜抗体，但与健康受试者或患有其他口腔黏膜疾病的患者相比，RAU患者中抗黏膜抗体阳性率（15/21，71%）和循环细胞间物质（ICS）抗体阳性率（14/21，67%）显著更高。在67%（14/21）的RAU患者的活动期，发现IgG类循环ICS抗体显著占主导。在一周的缓解期，该百分比按顺序降至25%（4/16），在两周的缓解期降至10%（1/10）。天疱疮样抗体的存在可能是由受损组织释放的表皮隐匿抗原引起的，和/或由于某些感染因子导致的短暂免疫调节功能障碍。
