复发性阿弗他溃疡发作期与缓解期的口腔黏膜抗原反应性。

Oral mucosal antigen reactivity during exacerbation and remission phases of recurrent aphthous ulceration.

作者信息

Lindemann R A, Riviere G R, Sapp J P

出版信息

Oral Surg Oral Med Oral Pathol. 1985 Sep;60(3):281-4. doi: 10.1016/0030-4220(85)90312-3.

PMID:3862041

Abstract

Pooled serum from subjects with active recurrent aphthous ulceration (RAU) and from control subjects was tested against indigenous surface mucosal material from subjects with active RAU, remission RAU subjects, and normal subjects. IgM antibody reactivity in both sera was significantly higher to material from remission RAU subject mucosa than to material from control subjects or subjects with active RAU. IgG antibody activity in both sera was significantly lower to material from active RAU subject mucosa than to material from control subjects or subjects whose RAU was in remission. These results suggest that the character and amount of antigen on mucosa may differ during the pathogenesis of RAU.

摘要

将患有复发性阿弗他溃疡（RAU）的受试者和对照受试者的混合血清，与患有活动性RAU的受试者、缓解期RAU受试者和正常受试者的自体表面粘膜材料进行检测。两种血清中的IgM抗体对缓解期RAU受试者粘膜材料的反应性显著高于对对照受试者或活动性RAU受试者材料的反应性。两种血清中的IgG抗体对活动性RAU受试者粘膜材料的活性显著低于对对照受试者或RAU处于缓解期受试者材料的活性。这些结果表明，在RAU发病机制中，粘膜上抗原的性质和数量可能有所不同。