动物模型中复合肌肉动作电位的波变化多样性

Variety of the Wave Change in Compound Muscle Action Potential in an Animal Model.

作者信息

Ito Zenya, Imagama Shiro, Ando Kei, Muramoto Akio, Kobayashi Kazuyoshi, Hida Tetsuro, Ito Kenyu, Ishikawa Yoshimoto, Tsushima Mikito, Matsumoto Akiyuki, Tanaka Satoshi, Morozumi Masayoshi, Matsuyama Yukihiro, Ishiguro Naoki

机构信息

Department of Orthopaedic Surgery, Nagoya University School of Medicine, Nagoya, Japan.

Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Nagoya, Japan.

出版信息

Asian Spine J. 2015 Dec;9(6):952-7. doi: 10.4184/asj.2015.9.6.952. Epub 2015 Dec 8.

STUDY DESIGN

Animal study.

PURPOSE

To review the present warning point criteria of the compound muscle action potential (CMAP) and investigate new criteria for spinal surgery safety using an animal model.

OVERVIEW OF LITERATURE

Little is known about correlation palesis and amplitude of spinal cord monitoring.

METHODS

After laminectomy of the tenth thoracic spinal lamina, 2-140 g force was delivered to the spinal cord with a tension gage to create a bilateral contusion injury. The study morphology change of the CMAP wave and locomotor scale were evaluated for one month.

RESULTS

Four different types of wave morphology changes were observed: no change, amplitude decrease only, morphology change only, and amplitude and morphology change. Amplitude and morphology changed simultaneously and significantly as the injury force increased (p<0.05) Locomotor scale in the amplitude and morphology group worsened more than the other groups.

CONCLUSIONS

Amplitude and morphology change of the CMAP wave exists and could be the key of the alarm point in CMAP.

研究设计

动物研究。

目的

回顾复合肌肉动作电位（CMAP）目前的警示点标准，并使用动物模型研究脊柱手术安全性的新标准。

文献综述

关于脊髓监测的相关性麻痹和幅度知之甚少。

方法

在第十胸椎椎板切除术后，用张力计向脊髓施加2 - 140克的力以造成双侧挫伤损伤。对CMAP波的研究形态变化和运动量表进行了为期一个月的评估。

结果

观察到四种不同类型的波形态变化：无变化、仅幅度降低、仅形态变化以及幅度和形态变化。随着损伤力增加，幅度和形态同时且显著变化（p<0.05）。幅度和形态组的运动量表比其他组恶化更严重。

结论

CMAP波的幅度和形态变化存在，并且可能是CMAP中警示点的关键。