Sun Ling, Tang Xiao-Ju, Luo Feng-Ming
Ling Sun, Xiao-Ju Tang, Laboratory of Cardiovascular Diseases Research Center of Regeneration Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
World J Methodol. 2015 Dec 26;5(4):223-9. doi: 10.5662/wjm.v5.i4.223.
The transcription factor forkhead box protein A2 (FOXA2, also known as hepatocyte nuclear factor 3β or transcription factor 3β), has been found to play pivotal roles in multiple phases of mammalian life, from the early development to the organofaction, and subsequently in homeostasis and metabolism in the adult. In the embryonic development period, FOXA2 is require d for the formation of the primitive node and notochord, and its absence results in embryonic lethality. Moreover, FOXA2 plays an important role not only in lung development, but also in T helper type 2 (Th2)-mediated pulmonary inflammation and goblet cell hyperplasia. In this article, the role of FOXA2 in lung development and Th2-mediated pulmonary inflammation, as well as in goblet cell hyperplasia, is reviewed. FOXA2 deletion in airway epithelium results into Th2-mediated pulmonary inflammation and goblet cell hyperplasia in developing lung. Leukotriene pathway and signal transducers and activators of transcription 6 pathway may mediate this inflammation through recruitment and activation of denditric cell during lung developments. FOXA2 is a potential treatment target for lung diseases with Th2 inflammation and goblet cell hyperplasia, such as asthma and chronic obstructive pulmonary disease.
转录因子叉头框蛋白A2（FOXA2，也称为肝细胞核因子3β或转录因子3β）已被发现，在哺乳动物生命的多个阶段发挥关键作用，从早期发育到器官功能形成，随后在成年期的体内平衡和新陈代谢中也发挥作用。在胚胎发育时期，FOXA2是原始节点和脊索形成所必需的，其缺失会导致胚胎致死。此外，FOXA2不仅在肺发育中起重要作用，还在2型辅助性T细胞（Th2）介导的肺部炎症和杯状细胞增生中起重要作用。本文综述了FOXA2在肺发育、Th2介导的肺部炎症以及杯状细胞增生中的作用。气道上皮细胞中FOXA2的缺失会导致发育中的肺出现Th2介导的肺部炎症和杯状细胞增生。白三烯途径以及信号转导和转录激活因子6途径可能在肺发育过程中通过募集和激活树突状细胞来介导这种炎症。FOXA2是治疗具有Th2炎症和杯状细胞增生的肺部疾病（如哮喘和慢性阻塞性肺疾病）的潜在靶点。
