Kantha S S
Kitasato Arch Exp Med. 1989 Apr;62(1):1-9.
One of the low points in Hideyo Noguchi's career as a pioneer medical microbiologist was his investigations on yellow fever between 1918 and 1924 in Central and South America. His discovery that spirochete Leptospira icteroides was the causative pathogen of yellow fever was discredited in 1927. This paper evaluates the situation under which Noguchi conducted his experiments and assesses the causes which might have resulted in his erroneous interpretation in the pre-electron microscopic era. Even 60 years after Noguchi's untimely death, much remains to be known about the virulence of pathogenic strains of yellow fever.
野口英世作为医学微生物学先驱的职业生涯中的一个低谷，是他在1918年至1924年期间在中美洲和南美洲对黄热病的研究。他发现黄疸钩端螺旋体是黄热病的致病病原体，但这一发现于1927年被否定。本文评估了野口英世进行实验的情况，并分析了在电子显微镜时代之前可能导致他错误解读的原因。即使在野口英世过早去世60年后，关于黄热病致病菌株的毒力仍有许多有待了解之处。
