Simic M G, Bergtold D S, Karam L R
National Institute of Standards and Technology, Gaithersburg, MD 20899.
Mutat Res. 1989 Sep;214(1):3-12. doi: 10.1016/0027-5107(89)90192-9.
Many recent lines of evidence indicate that endogenous free radicals contribute to spontaneous mutagenesis through the direct induction of DNA damage. However, the mechanisms underlying this process are not yet fully understood. A brief overview of the knowledge that is currently available is provided here, with emphasis on the generation of oxy radicals in biosystems, the reactions of those radicals with biomolecules, and the induction of oxidative DNA base damage that might lead to mutation.
最近的许多证据表明，内源性自由基通过直接诱导DNA损伤而导致自发突变。然而，这一过程背后的机制尚未完全了解。本文简要概述了目前已知的知识，重点是生物系统中氧自由基的产生、这些自由基与生物分子的反应，以及可能导致突变的氧化性DNA碱基损伤的诱导。
