Zhang Yunzhi, Baker Phillip J, Casabianca Leah B
Department of Chemistry, Clemson University , Clemson, South Carolina 29634, United States.
J Phys Chem B. 2016 Jan 14;120(1):18-24. doi: 10.1021/acs.jpcb.5b08741. Epub 2015 Dec 30.
The aromatic free radical BDPA (α,γ-bisdiphenylene-β-phenylallyl), which has been widely used as a polarizing agent for Dynamic Nuclear Polarization (DNP) of hydrophobic analytes, has been incorporated into nanometer-scale polystyrene latex beads. We have shown that the resulting BDPA-doped beads can be used to hyperpolarize (13)C and (7)Li nuclei in aqueous environments, without the need for a glassing cosolvent. DNP enhancement factors of between 20 and 100 were achieved with overall BDPA concentrations of 2 mM or less. These Highly-Effective Polymer/Radical Beads (HYPR-beads) have potential use as an inexpensive polarizing agent for water-soluble analytes, and also have applications as model nanoparticles in DNP studies.
芳香自由基BDPA（α，γ-双亚苯基-β-苯基烯丙基）已被广泛用作疏水性分析物动态核极化（DNP）的极化剂，现已被纳入纳米级聚苯乙烯胶乳珠中。我们已经表明，所得的BDPA掺杂珠可用于在水性环境中使（13）C和（7）Li核超极化，而无需玻璃化共溶剂。在BDPA总浓度为2 mM或更低的情况下，DNP增强因子达到20至100。这些高效聚合物/自由基珠（HYPR珠）有潜力用作水溶性分析物的廉价极化剂，并且在DNP研究中也可用作模型纳米颗粒。
