Wiklund N P, Ohlén A, Cederqvist B
Department of Physiology, Karolinska Institutet, Stockholm, Sweden.
Neurosci Lett. 1989 Jul 3;101(3):269-73. doi: 10.1016/0304-3940(89)90544-2.
Endothelin was tested for possible interactions with the noradrenergic neuroeffector transmission in guinea pig pulmonary artery. Endothelin concentration-dependently enhanced nerve-induced contractile responses and concomitantly increased basal tone. Furthermore, endothelin inhibited the stimulation-evoked release of [3H]noradrenaline and enhanced the contractile response to exogenously applied noradrenaline. These results suggest that endothelin, in addition to its direct contractile effect, may function as a modulator of adrenergic neuroeffector transmission in the guinea pig pulmonary artery via both stimulatory post- and inhibitory prejunctional mechanisms.
研究了内皮素与豚鼠肺动脉中去甲肾上腺素能神经效应传递之间可能存在的相互作用。内皮素浓度依赖性地增强神经诱导的收缩反应，并同时增加基础张力。此外，内皮素抑制刺激诱发的[3H]去甲肾上腺素释放，并增强对外源性应用去甲肾上腺素的收缩反应。这些结果表明，内皮素除了其直接收缩作用外，还可能通过刺激后和抑制节前机制，作为豚鼠肺动脉中肾上腺素能神经效应传递的调节剂发挥作用。
