Hoang-Xuan T, Foster C S, Raizman M B, Greenwood B
Harvard Medical School, Boston, MA.
Ophthalmology. 1989 Jul;96(7):1110-4. doi: 10.1016/s0161-6420(89)32790-4.
Ocular cicatricial pemphigoid (OCP) is characterized by progressive conjunctival subepithelial fibrosis often leading ultimately to corneal blindness. Mast cells have been shown to play a role in several fibrotic disorders, but the role of mast cells in OCP is unknown. The authors compared the mast cell population in conjunctival biopsy specimens from 14 OCP patients and from six controls by using specific histochemical stains for mast cell subsets. The total mast cell number and the ratio of connective tissue mast cells to mucosal mast cells (MMCs) were significantly higher in OCP than in normal conjunctiva (P less than 0.05). This report is the first analysis of mast cell subsets in human ocular tissue. The results suggest that connective tissue mast cells (CTMCs) may play an important role in OCP and that therapy directed toward mast cells and their mediators may be an appropriate avenue for further exploration.
眼瘢痕性类天疱疮（OCP）的特征是结膜上皮下进行性纤维化，最终常导致角膜盲。肥大细胞已被证明在几种纤维化疾病中起作用，但肥大细胞在OCP中的作用尚不清楚。作者通过使用针对肥大细胞亚群的特异性组织化学染色，比较了14例OCP患者和6例对照者结膜活检标本中的肥大细胞群体。OCP中肥大细胞总数以及结缔组织肥大细胞与黏膜肥大细胞（MMCs）的比例显著高于正常结膜（P<0.05）。本报告是对人类眼组织中肥大细胞亚群的首次分析。结果表明，结缔组织肥大细胞（CTMCs）可能在OCP中起重要作用，针对肥大细胞及其介质的治疗可能是进一步探索的合适途径。
