光学相干断层扫描成像用于识别甲状腺乳头状癌患者微小甲状腺外侵犯的初步研究。
Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma.
作者信息
Lee Hyoung Shin, Shin Sung Won, Bae Jung Kweon, Jung Woong Gyu, Kim Sung Won, Oak Chulho, Chun Bong Kwon, Ahn Yeh-Chan, Lee Byung-Joo, Lee Kang Dae
机构信息
Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, South Korea.
Innovative Biomedical Technology Research Center, College of Medicine, Kosin University, Busan, Korea.
出版信息
Lasers Surg Med. 2016 Apr;48(4):371-6. doi: 10.1002/lsm.22466. Epub 2015 Dec 31.
BACKGROUND AND OBJECTIVES
We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC).
METHODS
A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports.
RESULTS
The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively, for the first investigator, and 82.9% and 87.0%, respectively, for the second investigator. Substantial agreement between the investigators was verified by Cohen's κ (Cohen's κ = 0.772).
CONCLUSION
In this preliminary study of a limited series of ex vivo thyroidectomy specimens, we verified the feasibility of OCT as a method of identifying mETE in patients with PTC.
背景与目的
我们评估了使用光学相干断层扫描（OCT）来识别接受甲状腺切除术治疗乳头状甲状腺癌（PTC）患者的离体甲状腺切除标本中微小甲状腺外侵犯（mETE）的可行性。
方法
在17例患者甲状腺切除术后立即获取了总共170张肿瘤的离体OCT图像。两名盲法研究者分别对每位患者的OCT图像进行评估，并将结果与组织病理学报告进行比较。
结果
第一位研究者从OCT图像中识别mETE的敏感性和特异性分别为81.4%和86.0%，第二位研究者分别为82.9%和87.0%。研究者之间的高度一致性通过科恩κ检验得到验证（科恩κ = 0.772）。
结论
在这项对有限系列离体甲状腺切除标本的初步研究中，我们验证了OCT作为识别PTC患者mETE方法的可行性。
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