Radenkovic Miroslav, Stojanovic Marko, Prostran Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, PO Box 38, 11129 Belgrade, Serbia.
Curr Med Chem. 2016;23(19):2047-54. doi: 10.2174/0929867323666151231095126.
Endothelial dysfunction is principally characterized by impaired endothelium- dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.
内皮功能障碍主要表现为与血管舒张相关的内皮依赖性转导机制受损，这是由于内皮源性舒张因子（主要是一氧化氮）释放减少，以及氧化应激增强、炎症增加和内皮源性收缩因子产生的血管作用占主导地位所致。目前的数据有力地表明，不同类型的肾脏损伤的病理发展以及进一步进展为肾衰竭，包括与内皮功能障碍相关的显著血管变化。相应地，这一科学领域是一个不断发展的研究领域，涉及与肾损伤相关的内皮功能障碍的不同生物标志物，以及能提供对内皮功能障碍在肾脏疾病中的作用更全面理解的新信息的临床发现。关于引用的事实，本文的目的是通过选择2010年至2015年发表的相关文章，回顾与内皮功能障碍和肾衰竭相关的最新数据。
