免疫抑制药物在预防骨髓移植后移植物抗宿主病中的作用。
Role of immunosuppressive drugs for prevention of graft-v-host disease after bone marrow transplantation.
作者信息
Devergie A, Esperou H, Traineau R, Varrin F, Lehn P, Gluckman E
机构信息
Hôpital Saint-Louis, Unité Fonctionelle de Greffe de Moelle, Paris, France.
出版信息
Nouv Rev Fr Hematol (1978). 1989;31(2):73-5.
In a series of 198 patients we compared various methods of prevention of GVHD. One hundred and thirty-three patients were treated with CSA alone, 44 with the combination of CSA and MTX, and 21 with CSA after marrow T cell depletion. The incidence of GVHD greater than or equal to II was 35% in the CSA group, 22% in the CSA+MTX group and 14% in the T depleted group. The actuarial survival was 55.4%, 52.3% and 55.1% respectively. These results show that the improvement of methods of prevention of GVHD did not affect significantly long term survival after BMT.
在一组198例患者中，我们比较了预防移植物抗宿主病（GVHD）的各种方法。133例患者仅接受环孢素A（CSA）治疗，44例接受CSA与甲氨蝶呤（MTX）联合治疗，21例在骨髓T细胞清除后接受CSA治疗。CSA组中≥Ⅱ度GVHD的发生率为35%，CSA + MTX组为22%，T细胞清除组为14%。精算生存率分别为55.4%、52.3%和55.1%。这些结果表明，预防GVHD方法的改进对骨髓移植（BMT）后的长期生存没有显著影响。
Zotero 插件