FRMD3基因：其在糖尿病肾病中的作用。一篇叙述性综述。
FRMD3 gene: its role in diabetic kidney disease. A narrative review.
作者信息
Buffon Marjoriê Piuco, Sortica Denise Alves, Gerchman Fernando, Crispim Daisy, Canani Luís Henrique
机构信息
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, prédio 12, 4° andar, Porto Alegre, RS 90035-003 Brazil ; Endocrinology, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
出版信息
Diabetol Metab Syndr. 2015 Dec 30;7:118. doi: 10.1186/s13098-015-0114-4. eCollection 2015.
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
糖尿病肾病（DKD）是糖尿病的一种慢性并发症，被认为是一种全球性的流行病。为了阐明该疾病可能涉及的遗传因素，已经开展了多项研究。FRMD3基因是从全基因组关联研究（GWAS）中筛选出的一个有力候选基因，它编码参与维持细胞形状和完整性的结构蛋白4.1O。位于FRMD3基因上的一些单核苷酸多态性（SNP）在不同种族中都与DKD相关。然而，尽管有这些发现，此事仍存在争议。本叙述性综述的目的是总结关于FRMD3在DKD中作用的证据。
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