Jin Ming, Zhang Hao, Zhang Qi, Li Xueyan, Wu Nan, Hu Ying, Qiu Changchun, Wang Ningning, Zhang Keyong
Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing, China.
Int J Clin Exp Pathol. 2021 Jun 15;14(6):726-733. eCollection 2021.
There is a significant correlation between ischemic stroke (IS) and chromosome 9. However, its status was uncertain in China's cold regions. 1920 IS patients, and 1920 healthy individuals were included in the study. Blood samples were collected. The association of SNPs with IS was evaluated by Sequenom, and logistic regression models adjusted for known risk factors of IS were constructed to assess the SNPs' associations in cases and controls. We found rs1333040 and rs2383207 were associated with IS, compared with primitive genotypes. The genotype CT of rs7027526 has a protective role during IS development, while the effect of the genotype TT is still not clear. These results changed after stratification by age and sex. In conclusion, rs1333040 and rs2383207 SNPs in CDKN2BAS are associated with ischemic stroke in the Chinese Han population. This study confirms the association between 9p21.3 and IS.
缺血性中风（IS）与9号染色体之间存在显著相关性。然而，在中国寒冷地区其情况尚不确定。本研究纳入了1920例IS患者和1920名健康个体。采集了血液样本。通过Sequenom评估单核苷酸多态性（SNP）与IS的关联，并构建针对IS已知风险因素进行调整的逻辑回归模型，以评估病例组和对照组中SNP的关联。与原始基因型相比，我们发现rs1333040和rs2383207与IS相关。rs7027526的CT基因型在IS发生过程中具有保护作用，而TT基因型的作用仍不明确。按年龄和性别分层后这些结果发生了变化。总之，CDKN2BAS中的rs1333040和rs2383207单核苷酸多态性与中国汉族人群的缺血性中风相关。本研究证实了9p21.3与IS之间的关联。
