Al-Zoubi Mazhar Salim, Al-Tayyar Ibrahim Ali, Hussein Emad, Jabali Alla Al, Khudairat Salih
Biology Deparrment, Yarmouk University, Irbid, Jordan. ; Molecular Pathology Department, University of Pisa, Italy.
Department of Medical Laboratory Science, Faculty of Engineering & Technology, Brack, Sebha University, Lybia.
Iran J Microbiol. 2015 Oct;7(5):265-72.
The global spread of methicillin resistant Staphylococcus aureus (MRSA) constitutes one of the most serious contemporary challenges to the treatment of hospital-acquired infections. We aimed to screen and assess the antibiotic susceptibility pattern of Staphylococcus aureus isolated from clinical specimens in local hospitals of Northern province in Jordan.
Staphylococcus aureus was isolated and identified using standard methods from various clinical specimens of different infected body sites from 358 patients during the period from January 2008 to November 2012.
Our analysis showed that 31.6% of S. aureus infections were MRSA, while 31% were multidrug resistance (MDR) and 42.7% were Oxacillin-resistant (ORSA). Most of these strains were isolated from wound specimens. All isolates were susceptible to vancomycin (100%). They were also susceptible to chloramphenicol, linezolid, nitrofurantoin, rifampicin and teicoplanin (>80%), but showed resistance to erythromycin and penicillin.
Vancomycin was the most effective antimicrobial agent against S. aureus. We recommend regular surveillance of hospital associated infections and monitoring antibiotic sensitivity pattern and strict drug policy for antibiotics used within and outside the hospital environments.
耐甲氧西林金黄色葡萄球菌（MRSA）在全球范围内的传播是医院获得性感染治疗面临的最严峻当代挑战之一。我们旨在筛查和评估从约旦北部省份当地医院临床标本中分离出的金黄色葡萄球菌的抗生素敏感性模式。
在2008年1月至2012年11月期间，采用标准方法从358例患者不同感染身体部位的各种临床标本中分离并鉴定金黄色葡萄球菌。
我们的分析表明，31.6%的金黄色葡萄球菌感染为MRSA，31%为多重耐药（MDR），42.7%为耐苯唑西林（ORSA）。这些菌株大多从伤口标本中分离得到。所有分离株对万古霉素均敏感（100%）。它们对氯霉素、利奈唑胺、呋喃妥因、利福平及替考拉宁也敏感（>80%），但对红霉素和青霉素耐药。
万古霉素是对抗金黄色葡萄球菌最有效的抗菌药物。我们建议定期监测医院相关感染，监测抗生素敏感性模式，并对医院内外使用的抗生素制定严格的用药政策。
