Kaleem F, Usman J, Hassan A, Omair M, Khalid A, Uddin Roz
National University of Sciences and Technology, Department of Microbiology, Army Medical College, Rawalpindi, Pakistan.
Iran J Microbiol. 2010 Sep;2(3):143-6.
Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activities of different antibiotics against methicillin resistant Staphylococcus aureus.
The study was conducted over a period of one year (January 2009 - December 2009) in the Department of Microbiology, Army Medical College, the National University of Sciences and Technology, Pakistan. One hundred and thirty-nine Methicillin resistant Staphylococcus aureus isolated from the clinical specimens at Rawalpindi Military Hospital were subjected to in vitro susceptibility against various antimicrobials using Kirby Bauer disc diffusion technique.
All the isolated MRSA organisms were uniformly susceptible to vancomycin, linezolid and tigecycline. Other drugs which were found to be effective were chloramphenicol, and rifampacin. Most of the MRSA were isolated from pus samples.
Vancomycin, tigecycline and linezolid were effective against methicillin resistant strains of S.aureus. This study suggests that chloramphenicol and rifampacin also have good in vitro efficacy for methicillin resistant S. aureus infections. Oral dosing option for linezolid, chloramphenicol and rifampacin can allow earlier discharge of hospitalized patients and thus reduce health care expenses as well as help reduce the chances of vancomycin resistant strains emergence.
耐甲氧西林金黄色葡萄球菌（MRSA）是一种主要的医院病原体，可导致严重的发病和死亡。本研究的目的是评估不同抗生素对耐甲氧西林金黄色葡萄球菌的体外活性。
该研究于一年时间（2009年1月 - 2009年12月）在巴基斯坦国立科技大学陆军医学院微生物学系进行。从拉瓦尔品第军事医院临床标本中分离出的139株耐甲氧西林金黄色葡萄球菌，采用 Kirby Bauer 纸片扩散法对各种抗菌药物进行体外药敏试验。
所有分离出MRSA菌株均对万古霉素、利奈唑胺和替加环素敏感。其他被发现有效的药物有氯霉素和利福平。大多数MRSA菌株是从脓液样本中分离出来的。
万古霉素、替加环素和利奈唑胺对耐甲氧西林金黄色葡萄球菌菌株有效。本研究表明，氯霉素和利福平对耐甲氧西林金黄色葡萄球菌感染也具有良好的体外疗效。利奈唑胺、氯霉素和利福平的口服给药方式可使住院患者更早出院，从而降低医疗费用，并有助于减少耐万古霉素菌株出现的几率。
