Jusué-Torres Ignacio, Martinez-Gutierrez Juan Carlos, Elder Benjamin D, Olivi Alessandro
Department of Neurosurgery, Johns Hopkins University School of Medicine.
Cureus. 2015 Nov 20;7(11):e386. doi: 10.7759/cureus.386.
Trigeminal schwannomas represent between 0.07% and 0.36% of all intracranial tumors and 0.8% to 8% of intracranial schwannomas. Selection of the appropriate management strategy requires an understanding of the tumor's natural history and treatment outcomes. This report describes the case of a 36-year-old male who presented with a three-month history of progressive headaches, dizziness, loss of balance, decreased sleep, and cognitive decline. Magnetic resonance imaging revealed a large enhancing lesion centered around the left Meckel's cave and extending into both the middle and the posterior fossa with obstructive hydrocephalus secondary to compression of the fourth ventricle. Resection of the posterior fossa component of the tumor was performed in order to relieve the mass effect upon the brainstem without attempting a radical removal of the middle fossa component and a potential risk of further cognitive impairment. The pathological exam confirmed the diagnosis of a trigeminal schwannoma. The residual tumor showed progressive spontaneous volumetric shrinkage after a subtotal surgical resection. This case shows the value of a planned conservative surgery in complex schwannomas and highlights the challenges in interpreting the treatment responses in these benign tumors, whether approached surgically or with stereotactic radiation techniques.
三叉神经鞘瘤占所有颅内肿瘤的0.07%至0.36%,占颅内神经鞘瘤的0.8%至8%。选择合适的治疗策略需要了解肿瘤的自然病史和治疗结果。本报告描述了一名36岁男性患者的病例,该患者有三个月进行性头痛、头晕、平衡失调、睡眠减少和认知能力下降的病史。磁共振成像显示一个大的强化病灶,以左侧梅克尔腔为中心,延伸至中颅窝和后颅窝,因第四脑室受压继发梗阻性脑积水。为了减轻对脑干的占位效应,对肿瘤的后颅窝部分进行了切除,而未试图彻底切除中颅窝部分,以避免进一步认知障碍的潜在风险。病理检查确诊为三叉神经鞘瘤。次全手术切除后,残留肿瘤显示出自发性体积逐渐缩小。该病例显示了在复杂神经鞘瘤中进行计划性保守手术的价值,并突出了在解释这些良性肿瘤的治疗反应时所面临的挑战,无论采用手术治疗还是立体定向放射技术。