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经海绵窦入路全切除哑铃形巨大三叉神经鞘瘤

Transcavernous Approach for Gross Total Resection of a Dumbbell-Shaped Giant Trigeminal Schwannoma.

作者信息

Sayyahmelli Sima, Avci Emel, Ozaydin Burak, Başkaya Mustafa K

机构信息

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

出版信息

J Neurol Surg B Skull Base. 2021 May 17;83(Suppl 3):e648-e649. doi: 10.1055/s-0041-1729995. eCollection 2022 Aug.

Abstract

Trigeminal schwannomas are rare nerve sheet tumors that represent the second most common intracranial site of occurrence after vestibular nerve origins. Microsurgical resection of giant dumbbell-shaped trigeminal schwannomas often requires complex skull base approaches. The extradural transcavernous approach is effective for the resection of these giant tumors involving the cavernous sinus. The patient is a 72-year-old man with headache, dizziness, imbalance, and cognitive decline. Neurological examination revealed left-sided sixth nerve palsy, a diminished corneal reflex, and wasting of temporalis muscle. Magnetic resonance imaging (MRI) showed a giant homogeneously enhancing dumbbell-shaped extra-axial mass centered within the left cavernous sinus, Meckel's cave, and the petrous apex, with extension to the cerebellopontine angle. There was a significant mass effect on the brain stem causing hydrocephalus. Computed tomography (CT) scan showed erosion of the petrous apex resulting in partial anterior autopetrosectomy ( Figs. 1 and 2 ). The decision was made to proceed with tumor resection using a transcavernous approach. Gross total resection was achieved. The surgery and postoperative course were uneventful, and the patient woke up the same as in the preoperative period. MRI confirmed gross total resection of the tumor. The histopathology was a trigeminal schwannoma, World Health Organization (WHO) grade I. The patient continues to do well without any recurrence at 15-month follow-up. This video demonstrates important steps of the microsurgical skull base techniques for resection of these challenging tumors. The link to the video can be found at https://youtu.be/TMK5363836M.

摘要

三叉神经鞘瘤是罕见的神经鞘膜肿瘤,是继前庭神经起源部位之后第二常见的颅内发病部位。巨大哑铃形三叉神经鞘瘤的显微手术切除通常需要采用复杂的颅底入路。硬膜外经海绵窦入路对于切除累及海绵窦的这些巨大肿瘤是有效的。患者为一名72岁男性,有头痛、头晕、平衡失调和认知功能减退症状。神经系统检查发现左侧展神经麻痹、角膜反射减弱和颞肌萎缩。磁共振成像(MRI)显示一个巨大的、均匀强化的哑铃形轴外肿块,位于左侧海绵窦、 Meckel腔和岩尖内,延伸至桥小脑角。对脑干有明显的占位效应,导致脑积水。计算机断层扫描(CT)显示岩尖骨质侵蚀,导致部分前路岩骨切除术(图1和图2)。决定采用经海绵窦入路进行肿瘤切除。实现了肿瘤全切。手术及术后过程顺利,患者术后苏醒情况与术前相同。MRI证实肿瘤已全切。组织病理学检查为三叉神经鞘瘤,世界卫生组织(WHO)I级。在15个月的随访中,患者情况良好,无任何复发。本视频展示了切除这些具有挑战性肿瘤的显微颅底手术技术的重要步骤。视频链接可在https://youtu.be/TMK5363836M找到。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/611c/9440937/301567d99965/10-1055-s-0041-1729995-i200151ov-1.jpg

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