• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

A minimal ING1b fragment that improves the efficacy of HDAC-based cancer cell killing.

作者信息

Boyko A, Riabowol K

机构信息

Departments of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada.

Department of Oncology, University of Calgary, Calgary, Alberta, Canada.

出版信息

Cell Death Dis. 2015 Dec 31;6(12):e2027. doi: 10.1038/cddis.2015.376.

DOI:10.1038/cddis.2015.376
PMID:26720336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4720907/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e622/4720907/ebee4a0d39a8/cddis2015376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e622/4720907/ebee4a0d39a8/cddis2015376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e622/4720907/ebee4a0d39a8/cddis2015376f1.jpg

相似文献

1
A minimal ING1b fragment that improves the efficacy of HDAC-based cancer cell killing.一种可提高基于组蛋白去乙酰化酶的癌细胞杀伤效果的最小ING1b片段。
Cell Death Dis. 2015 Dec 31;6(12):e2027. doi: 10.1038/cddis.2015.376.
2
Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.肿瘤抑制因子 sFRP1 的重新表达导致组蛋白去乙酰化酶和甲基转移酶抑制剂联合应用于化疗耐药癌症时产生抗肿瘤协同作用。
Mol Cancer Ther. 2012 Oct;11(10):2105-15. doi: 10.1158/1535-7163.MCT-11-0873. Epub 2012 Jul 23.
3
HDAC inhibitors induce cell cycle arrest, activate the apoptotic extrinsic pathway and synergize with a novel PIM inhibitor in Hodgkin lymphoma-derived cell lines.
Br J Haematol. 2011 Feb;152(3):352-6. doi: 10.1111/j.1365-2141.2010.08401.x. Epub 2010 Oct 19.
4
ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.ING1 和 5-氮杂胞苷协同作用,阻断乳腺癌细胞生长。
PLoS One. 2012;7(8):e43671. doi: 10.1371/journal.pone.0043671. Epub 2012 Aug 20.
5
ING1b-inducible microRNA203 inhibits cell proliferation.ING1b 诱导的 microRNA203 抑制细胞增殖。
Br J Cancer. 2013 Mar 19;108(5):1143-8. doi: 10.1038/bjc.2013.50. Epub 2013 Mar 5.
6
Tumor suppressor Ing1b facilitates DNA repair and prevents oxidative stress induced cell death.抑癌基因 Ing1b 促进 DNA 修复并防止氧化应激诱导的细胞死亡。
Apoptosis. 2014 Mar;19(3):518-26. doi: 10.1007/s10495-013-0940-5.
7
Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells.肿瘤抑制因子p33(ING1b)在丝氨酸126处的磷酸化影响其蛋白质稳定性及黑色素瘤细胞的增殖。
FASEB J. 2007 Nov;21(13):3705-16. doi: 10.1096/fj.07-8069com. Epub 2007 Jun 21.
8
Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines.I 类组蛋白去乙酰化酶(HDAC)抑制优于泛 HDAC 抑制,可调节高级别浆液性卵巢癌细胞系中顺铂的效力。
Int J Mol Sci. 2019 Jun 22;20(12):3052. doi: 10.3390/ijms20123052.
9
Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody.胰腺肿瘤先前暴露于 [索拉非尼+伏立诺他] 可增强抗 PD-1 抗体的疗效。
Cancer Biol Ther. 2019;20(1):109-121. doi: 10.1080/15384047.2018.1507258. Epub 2018 Aug 24.
10
Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents.伏立诺他是一种组蛋白去乙酰化酶(HDAC)抑制剂,可促进细胞周期停滞,并使利妥昔单抗和化疗耐药的淋巴瘤细胞对化疗药物重新敏感。
J Cancer Res Clin Oncol. 2016 Feb;142(2):379-87. doi: 10.1007/s00432-015-2026-y. Epub 2015 Aug 28.

本文引用的文献

1
Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis.确定能够有效诱导细胞凋亡的ING1b肿瘤抑制因子的最小肽序列。
Cell Death Discov. 2015 Oct 26;1:15048. doi: 10.1038/cddiscovery.2015.48. eCollection 2015.
2
Keep-ING balance: tumor suppression by epigenetic regulation.维持平衡:表观遗传调控的肿瘤抑制作用。
FEBS Lett. 2014 Aug 19;588(16):2728-42. doi: 10.1016/j.febslet.2014.03.011. Epub 2014 Mar 14.
3
ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.
ING1 和 5-氮杂胞苷协同作用,阻断乳腺癌细胞生长。
PLoS One. 2012;7(8):e43671. doi: 10.1371/journal.pone.0043671. Epub 2012 Aug 20.
4
Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.核仁蛋白 CSIG 是 UV 诱导细胞凋亡中 p33ING1 功能所必需的。
Cell Death Dis. 2012 Mar 15;3(3):e283. doi: 10.1038/cddis.2012.22.
5
The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells.抑生长因子 1(ING1)参与曲古抑菌素 A 诱导的 p53 缺陷型脑胶质瘤细胞凋亡和 caspase 3 信号通路。
Oncol Res. 2010;18(10):469-80. doi: 10.3727/096504010x12704916124828.
6
Tethering by lamin A stabilizes and targets the ING1 tumour suppressor.通过核纤层蛋白A进行的拴系作用可稳定ING1肿瘤抑制因子并使其靶向定位。
Nat Cell Biol. 2008 Nov;10(11):1333-40. doi: 10.1038/ncb1792. Epub 2008 Oct 5.
7
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.ING2植物同源结构域识别组蛋白H3K4me3的分子机制
Nature. 2006 Jul 6;442(7098):100-3. doi: 10.1038/nature04814. Epub 2006 May 21.
8
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.ING肿瘤抑制蛋白是基因组表达和延续所需的染色质乙酰化的关键调节因子。
Mol Cell. 2006 Jan 6;21(1):51-64. doi: 10.1016/j.molcel.2005.12.007.
9
p33(ING1) enhances UVB-induced apoptosis in melanoma cells.p33(ING1)增强紫外线B诱导的黑色素瘤细胞凋亡。
Exp Cell Res. 2002 Oct 1;279(2):291-8. doi: 10.1006/excr.2002.5610.
10
UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences.紫外线通过两个不同的核仁靶向序列诱导ING1发生核仁易位。
Nucleic Acids Res. 2001 May 15;29(10):2052-8. doi: 10.1093/nar/29.10.2052.