咖啡因可增强米安色林和阿戈美拉汀在小鼠强迫游泳和悬尾试验中的抗抑郁样活性。
Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice.
作者信息
Poleszak Ewa, Szopa Aleksandra, Wyska Elżbieta, Kukuła-Koch Wirginia, Serefko Anna, Wośko Sylwia, Bogatko Karolina, Wróbel Andrzej, Wlaź Piotr
机构信息
Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
出版信息
Pharmacol Rep. 2016 Feb;68(1):56-61. doi: 10.1016/j.pharep.2015.06.138. Epub 2015 Jul 17.
BACKGROUND
The main goal of this research was an evaluation of the influence of caffeine on the activity of mianserin and agomelatine.
METHODS
The mouse forced swim test and tail suspension test were used to determine the influence of caffeine on the activity of the tested drugs. Drug concentrations in serum and brains were estimated by HPLC.
RESULTS
Caffeine increases the anti-immobility action of mianserin and agomelatine. The observed effects were not associated with changes in the level of drugs in serum or brains.
CONCLUSION
The synergistic effect of caffeine and the tested drugs may be associated with their summative actions on monoaminergic neurotransmission. Caffeine-mianserin and caffeine-agomelatine interactions might have been of pharmacodynamic origin.
背景
本研究的主要目的是评估咖啡因对米氮平和阿戈美拉汀活性的影响。
方法
采用小鼠强迫游泳试验和悬尾试验来确定咖啡因对受试药物活性的影响。通过高效液相色谱法估算血清和脑中的药物浓度。
结果
咖啡因增强了米氮平和阿戈美拉汀的抗不动作用。观察到的效应与血清或脑中药物水平的变化无关。
结论
咖啡因与受试药物的协同效应可能与其对单胺能神经传递的累加作用有关。咖啡因 - 米氮平和咖啡因 - 阿戈美拉汀的相互作用可能源于药效学。
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