Wośko Sylwia, Serefko Anna, Szopa Aleksandra, Kardaś Sylwia, Widelski Jarosław, Mroczek Tomasz, Rostkowska Ewelina, Szymańska Jolanta, Poleszak Ewa
Laboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
Student's Scientific Circle at Laboratory of Preclinical Testing, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.
Life (Basel). 2021 Oct 21;11(11):1117. doi: 10.3390/life11111117.
Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, , belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs.
抑郁症是世界上最常见的精神障碍之一，会对患者的日常功能产生负面影响。目前正在进行大量研究，以检验新型合成化合物和草药的抗抑郁潜力。雪莲果属于具有多种有益健康特性的植物。以雪莲果为基础的产品被视为功能性食品。在我们的研究中，我们试图检验给予雪莲果块茎提取物是否会对小鼠的强迫游泳试验（FST）产生抗抑郁作用，以及其摄入是否会影响具有不同作用机制的传统抗抑郁药物的活性，即盐酸丙咪嗪、盐酸氟西汀和甲磺酸瑞波西汀。还研究了受试小鼠的自发运动活动，以消除任何假阳性结果。我们证明，以100mg/kg的剂量胃内给予雪莲果块茎提取物可诱导小鼠在FST中出现类似抗抑郁的行为，并且将雪莲果提取物的亚有效剂量（50mg/kg）与盐酸丙咪嗪（7.5mg/kg）、盐酸氟西汀（20mg/kg）或甲磺酸瑞波西汀（5mg/kg）联合给药可显著缩短动物在该行为试验中的不动时间。所得结果不受受试对象运动活动增加的影响。总之，我们的研究结果表明，雪莲果块茎提取物有望成为一种改善情绪的替代产品，因为它具有抗抑郁潜力，并且可以与传统抗抑郁药物协同作用。
