School of Materials Science and Engineering, Pusan National University, Busan, 609-735 Republic of Korea.
School of Nano and Advanced Materials, Gyeongsang National University, Jinju, Gyeongnam 660-701 Republic of Korea.
Biomater Res. 2015 Dec 31;19:14. doi: 10.1186/s40824-015-0036-0. eCollection 2015.
Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-situ formed BCP consisting of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of in-situ formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures.
The crystal phases, Ca/P molar ratio, and lattice parameters of in-situ formed BCP consisting of HAp and β-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis.
The long and short range order structural changes of in-situ formed BCP might be due to the coexistence of β-TCP and HAp crystal phases.
双相磷酸钙（BCP）作为骨移植替代物受到了广泛关注。本研究采用水相共沉淀和煅烧法制备 BCP。通过前驱体的钙缺失程度控制原位形成的 BCP 中由羟基磷灰石（HAp）和β-磷酸三钙（β-TCP）组成的晶体相。使用 Rietveld 精修技术和高分辨率拉曼光谱研究了双相混合物的长程和短程有序结构。原位形成的 BCP 的精修结构参数证实，所有研究的结构均已结晶为相应的六方（空间群 P63/m）和菱方（空间群 R3c）结构。
通过磷酸钙前驱体的钙缺失程度控制了由 HAp 和 β-TCP 组成的原位形成的 BCP 的晶体相、Ca/P 摩尔比和晶格参数。拉曼分析确定了 BCP 的显著短程有序结构变化。
原位形成的 BCP 的长程和短程有序结构变化可能是由于β-TCP 和 HAp 晶体相的共存所致。
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