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[女性何时以及为何应筛查高雄激素血症?]

[When and why should hyperandrogenism be searched for in women?].

作者信息

Buvat J

机构信息

Association pour l'étude de la Pathologie de l'Appareil Reproducteur et de la Psychomatique (EPARP), Lille.

出版信息

Rev Fr Gynecol Obstet. 1989 Jun;84(6):483-8.

PMID:2672267
Abstract

It is important to diagnose hyperandrogenism in women. By disturbing ovulation, it is actually one of the most frequent causes of infertility. In this particular case, its diagnosis has specific implications: sometimes specific treatment is indicated, or the risk of fetal virilization should be prevented. There is always the possibility of a diagnosis of polycystic ovary, prompting precautionary measures to be taken that are likely to limit the risks linked to the multifollicular development that is so frequent with this disorder. In addition, hyperandrogenism exposes the patient to various gynecological and general complications: cancer of the endometrium, progressive increase in menstrual disturbances and infertility, obesity, metabolic disturbances and probably increase in cardiovascular risks. Certain types of hyperandrogenism give rise to diseases that expose the patient to specific risks: virilizing tumors, Cushing's syndrome, neonatal risks linked to congenital hyperplasia of the adrenal glands. Hyperandrogenism should be borne in mind not only when the clinical picture is that of virilization, but also when there is any disturbance in eugonadal ovulation, whether or not this is manifested as menstrual disturbances or as infertility, and especially whether or not it is accompanied by hirsutism.

摘要

诊断女性高雄激素血症很重要。它通过干扰排卵,实际上是不孕症最常见的原因之一。在这种特殊情况下,其诊断有特定的意义:有时需要进行特定治疗,或者应预防胎儿男性化的风险。总是有可能诊断为多囊卵巢,这就需要采取预防措施,这些措施可能会降低与该疾病常见的多卵泡发育相关的风险。此外,高雄激素血症会使患者面临各种妇科和全身并发症:子宫内膜癌、月经紊乱和不孕症逐渐加重、肥胖、代谢紊乱以及心血管风险可能增加。某些类型的高雄激素血症会引发一些使患者面临特定风险的疾病:男性化肿瘤、库欣综合征、与先天性肾上腺增生相关的新生儿风险。不仅在临床表现为男性化时,而且在性腺功能正常的排卵出现任何紊乱时,无论这种紊乱是否表现为月经紊乱或不孕症,尤其是无论是否伴有多毛症,都应考虑高雄激素血症。

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Rev Fr Gynecol Obstet. 1989 Jun;84(6):483-8.
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