Sırav Bahriye, Seyhan Nesrin
Gazi University, Faculty of Medicine, Department of Biophysics, Ankara, Turkey; Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey.
Gazi University, Faculty of Medicine, Department of Biophysics, Ankara, Turkey; Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey.
J Chem Neuroanat. 2016 Sep;75(Pt B):123-7. doi: 10.1016/j.jchemneu.2015.12.010. Epub 2015 Dec 23.
With the increased use of mobile phones, their biological and health effects have become more important. Usage of mobile phones near the head increases the possibility of effects on brain tissue. This study was designed to investigate the possible effects of pulse modulated 900MHz and 1800MHz radio-frequency radiation on the permeability of blood-brain barrier of rats. Study was performed with 6 groups of young adult male and female wistar albino rats. The permeability of blood-brain barrier to intravenously injected evans blue dye was quantitatively examined for both control and radio-frequency radiarion exposed groups. For male groups; Evans blue content in the whole brain was found to be 0.08±0.01mg% in the control, 0.13±0.03mg% in 900MHz exposed and 0.26±0.05mg% in 1800MHz exposed animals. In both male radio-frequency radiation exposed groups, the permeability of blood-brain barrier found to be increased with respect to the controls (p<0.01). 1800MHz pulse modulated radio-frequency radiation exposure was found more effective on the male animals (p<0.01). For female groups; dye contents in the whole brains were 0.14±0.01mg% in the control, 0.24±0.03mg% in 900MHz exposed and 0.14±0.02mg% in 1800MHz exposed animals. No statistical variance found between the control and 1800MHz exposed animals (p>0.01). However 900MHz pulse modulated radio-frequency exposure was found effective on the permeability of blood-brain barrier of female animals. Results have shown that 20min pulse modulated radio-frequency radiation exposure of 900MHz and 1800MHz induces an effect and increases the permeability of blood-brain barrier of male rats. For females, 900MHz was found effective and it could be concluded that this result may due to the physiological differences between female and male animals. The results of this study suggest that mobile phone radation could lead to increase the permeability of blood-brain barrier under non-thermal exposure levels. More studies are needed to demonstrate the mechanisms of that breakdown.
随着手机使用的增加，其对生物和健康的影响变得更加重要。在头部附近使用手机会增加对脑组织产生影响的可能性。本研究旨在调查脉冲调制的900MHz和1800MHz射频辐射对大鼠血脑屏障通透性的可能影响。研究使用了6组年轻成年雄性和雌性Wistar白化大鼠。对对照组和暴露于射频辐射的组，定量检测了血脑屏障对静脉注射伊文思蓝染料的通透性。对于雄性组；对照组全脑中伊文思蓝含量为0.08±0.01mg%，900MHz暴露组为0.13±0.03mg%，1800MHz暴露组为0.26±0.05mg%。在两个暴露于射频辐射的雄性组中，血脑屏障的通透性相对于对照组均有所增加（p<0.01）。发现1800MHz脉冲调制射频辐射暴露对雄性动物的影响更大（p<0.01）。对于雌性组；对照组全脑中染料含量为0.14±0.01mg%，900MHz暴露组为0.24±0.03mg%，1800MHz暴露组为0.14±0.02mg%。在对照组和1800MHz暴露组动物之间未发现统计学差异（p>0.01）。然而，发现900MHz脉冲调制射频暴露对雌性动物的血脑屏障通透性有影响。结果表明，900MHz和1800MHz的20分钟脉冲调制射频辐射暴露会产生影响并增加雄性大鼠血脑屏障的通透性。对于雌性，发现900MHz有影响，可以得出结论，这一结果可能归因于雌性和雄性动物之间的生理差异。本研究结果表明，在非热暴露水平下，手机辐射可能导致血脑屏障通透性增加。需要更多研究来证明这种破坏的机制。
