Baniak Nick M, Wilde Brent, Kanthan Rani
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Pathol Res Pract. 2016 Feb;212(2):125-9. doi: 10.1016/j.prp.2015.12.006. Epub 2015 Dec 11.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, likely under recognized entity. We report on six cases of DIPNECH that were seen in Saskatoon, SK. The cases largely have the characteristics of the typical patient profile thus far described in the literature, consistent with the limited information reported to date. Furthermore, one case had co-existing squamous cell carcinoma, which has not been previously described, and one case had concomitant adenocarcinoma. In this context, we explore the hypothesis of whether DIPNECH could play a role as an uncommon precursor in pulmonary tumorigenesis. We also propose improved diagnostic criteria for DIPNECH, which are currently ill-defined.
弥漫性特发性肺神经内分泌细胞增生症（DIPNECH）是一种罕见的、可能未被充分认识的病症。我们报告了在加拿大萨斯喀彻温省萨斯卡通市所见的6例DIPNECH病例。这些病例在很大程度上具有迄今为止文献中所描述的典型患者特征，与迄今报告的有限信息一致。此外，1例病例合并存在鳞状细胞癌，这在之前未曾有过描述，还有1例病例伴有腺癌。在此背景下，我们探讨DIPNECH是否可能作为肺肿瘤发生中一种不常见的前体发挥作用这一假说。我们还提出了目前定义不明确的DIPNECH的改进诊断标准。
